ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Association of plasma fibronectin level with left atrial electrical and structural remodelling in lone paroxysmal atrial fibrillation: a cross-sectional study [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2015; 43(3): 259-268 | DOI: 10.5543/tkda.2015.83893

Association of plasma fibronectin level with left atrial electrical and structural remodelling in lone paroxysmal atrial fibrillation: a cross-sectional study

Uğur Canpolat1, Ali Oto2, Hikmet Yorgun2, Hamza Sunman3, Levent Şahiner2, Ergün Barış Kaya2, Necla Özer2, Kudret Aytemir2
1Cardiology Clinic, Türkiye Yüksek İhtisas Training And Rsearch Hospital, Ankara, Turkey
2Department Of Cardiology, Hacettepe University Faculty Of Medicine, Ankara, Turkey
3Cardiology Clinic, Dıskapi Training And Rsearch Hospital, Ankara, Turkey


OBJECTIVE
Atrial fibrosis is one of the main components of atrial fibrillation (AF) pathophysiology and culminates in structural, electrical and contractile remodelling. Fibronectin is one of the well-known mediators of fibrogenesis. However, the association of plasma fibronectin with atrial remodelling has not been studied previously. Therefore, the aim of this study was to assess the relationship between plasma fibronectin level and atrial electrical and structural remodelling in patients with lone paroxysmal AF.

METHODS
A total of 51 lone paroxysmal AF patients and 40 age-, gender- and body mass index-matched healthy control subjects were enrolled. Plasma levels of fibronectin and high sensitive C-reactive protein (hs-CRP) were measured and transthoracic echocardiography for assessment of total atrial conduction time (TACT) and left atrial (LA) volume index was performed on all study participants.

RESULTS
Plasma fibronectin, hs-CRP, TACT, LA diameter and LA volume index were significantly higher in lone paroxysmal AF group compared to healthy controls (p<0.05). Also, there was a positive correlation between plasma fibronectin level and TACT (r=0.362, p<0.001) and LA volume index (r=0.371, p<0.001). In multivariate logistic regression analysis, age, plasma fibronectin level (Odds ratio - OR: 1.003, 95% CI: 1.001-1.005, p=0.026) and hs-CRP (OR: 2.312, 95% CI: 1.503-6.459, p=0.017) were found to be the predictors of LA structural remodelling; however, only plasma fibronectin level (OR: 1.003, 95% CI: 1.001-1.005, p=0.032) and hs-CRP (OR: 3.212, 95% CI: 1.214-5.752, p=0.033) were found as the predictors of LA electrical remodelling.

CONCLUSION
Our study results showed that profibrotic and proinflammatory biomarkers were associated with left atrial structural and electrical remodelling in lone paroxysmal AF patients.

Keywords: Atrial fibrillation, fibronectins; heart atria; transthoracic echocardiography

How to cite this article
Uğur Canpolat, Ali Oto, Hikmet Yorgun, Hamza Sunman, Levent Şahiner, Ergün Barış Kaya, Necla Özer, Kudret Aytemir. Association of plasma fibronectin level with left atrial electrical and structural remodelling in lone paroxysmal atrial fibrillation: a cross-sectional study. Turk Kardiyol Dern Ars. 2015; 43(3): 259-268

Corresponding Author: Uğur Canpolat, Türkiye
Manuscript Language: Turkish


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Journal Citation Indicator: 0.18
CiteScore: 1.1
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SCImago Journal Rank: 0.348

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