Turk Kardiyol Dern Ars. Ahead of Print: TKDA-69765 | DOI: 10.5543/tkda.2022.69765

The effects of Curcumin on mechanical functions and cardiac contractility in isolated rat hearts

Özden Kutlay¹, Bilgin Kaygısız², Arzu Keskin Aktan^1
1Afyonkarahisar Health Sciences University, Faculty of Medicine, Department of Physiology, Afyonkarahisar, Turkey
²Department of Pharmacology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Türkiye

Objectıve: Curcumin is a bioactive compound that has well-known pharmacological activities. Numerous studies appeared to curcumin exerts potential cardiovascular benefits through various mechanisms. The present study aims to discuss different concentrations of curcumin’s impact on mechanical functions and cardiac contractility in isolated perfused rat hearts.


METHODS
The hearts were isolated under sodium thiopental (50 mg/kg) anesthesia and perfused with a modified Krebs-Henseleit solution (mK-Hs). After stabilization, curcumin was applied in concentrations of 0.1, 1, and 10 µM. In isolated rat hearts, indexes of + dP / dt max, LVDP, and LVEDP were evaluated for cardiac contractility and ventricular function.
RESULTS
All curcumin concentrations reduced +dP/dtmax and LVDP.. Ten µM curcumin also significantly decreased heart rate. Curcumin (1 and 10 µM ) increased LVEDP and reduced MAP amplitude with a concomitant increase in MAP duration. Curcumin at all concentrations did not affect dMAPdtmax and dMAPdtmin.

Conclusıon: Our results might suggest that curcumin at higher concentrations (≥ 1 µM) increases LVEDP with a negative chronotropic effect and decreases MAP amplitude with an increase in MAP duration. There is sufficient evidence from this study that Curcumin possesses an adverse inotropic action. Different disease models should support the pathophysiological role of Curcumin on cardiac contraction.

Keywords: Animal model, autonomic nervous system, curcumin, heart rate, cardiac contractility, left ventricular end-diastolic pressure, ısolated rat heart, hemodynamics

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