EDITORIAL COMMENT | |
1. | Global burden of chronic kidney disease and decreased kidney function in Turkish heart failure patients Guliz Kozdag Gold PMID: 32633268 doi: 10.5543/tkda.2020.80303 Pages 451 - 453 Abstract | English Full Text |
ORIGINAL ARTICLE | |
2. | NT-proBNP level in stage 3-4 chronic kidney disease and mortality in long-term follow-up: HAPPY study subgroup analysis Mustafa Aytek Şimşek, Muzaffer Değertekin, Ayça Türer Cabbar, Burak Hünük, Serkan Aktürk, Siyar Erdoğmuş, Bülent Mutlu, Ömer Kozan PMID: 32633264 doi: 10.5543/tkda.2020.57746 Pages 454 - 460 Objective: This was an investigation of the relationship between the N-terminal pro-brain natriuretic peptide (NT-proBNP) level and mortality in patients with stage 3-4 chronic kidney disease (CKD). Methods: This study was designed as a subgroup analysis of the Heart Failure Prevalence and Predictors in Turkey (HAPPY) study. The HAPPY study included 4650 randomly selected individuals from the 7 geographical regions of Turkey. A total of 191 subjects from the original cohort with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.1.73 m² were enrolled in this study and the relationship between NT-proBNP and mortality was investigated. Prognostic variables for total and cardiovascular mortality were also examined using Cox regression analysis. Results: The mean length of follow-up was 76.12±22.45 months. The mean NT-proBNP level was 423.54±955.88 pg/mL. During follow-up, 51 subjects (26.7%) died from any cause and 36 subjects (18.8%) died from a cardiovascular cause. The presence of hypertension (hazard ratio [HR]: 1.89; 95% confidence interval [CI]: 1.01–3.50; p=0.048), anemia (HR: 2.49; 95% CI: 1.20–5.15; p=0.014), male gender (HR: 2.64; 95% CI: 1.44–4.86; p=0.002) and log NT-proBNP (HR: 4.93; 95% CI: 2.83-8.58; p<0.001) were independent variables for total mortality. The presence of hypertension (HR: 2.47; 95% CI: 1.09–5.56; p=0.029), male gender (HR: 2.79; 95% CI: 1.38–5.62; p=0.004), eGFR (HR: 0.94; 95% CI: 0.91–0.98; p=0.005) and log NT-proBNP (HR: 6.31; 95% CI: 3.11–12.81; p<0.001) were independent predictors of cardiovascular mortality. Conclusion: NT-proBNP was found to be an independent prognostic marker in patients with stage 3–4 CKD. |
3. | Association of APOA5-1131T>C polymorphism with obesity in coronary artery disease Neslihan Çoban, Aybike Sena Özuynuk, Aycan Fahri Erkan, Berkay Ekici, Maide Kaşit, Nihan Erginel Ünaltuna PMID: 32633266 doi: 10.5543/tkda.2020.62874 Pages 461 - 471 Objective: Genetic risk factors that cause coronary artery disease (CAD) demonstrate variations in different populations. In this study, a single nucleotide polymorphism in the APOA5 gene was targeted to determine genetic contributors to atherosclerotic CAD. The effects of this polymorphism on the development of CAD and known risk factors of the disease were examined. Methods: A total of 448 patients with angina or acute myocardial infarction who underwent coronary angiography were grouped as individuals with normal coronary arteries (≤30% stenosis) and critical disease (≥50% stenosis). The angiographic severity and the extent of atherosclerotic CAD were assessed using the Gensini and SYNTAX scores. Individuals were genotyped for the APOA5−1131T>C polymorphism using hydrolysis probes and the results were evaluated. Results: The APOA5−1131T>C polymorphism was associated with the serum lipid levels in the non-CAD group (p<0.05). In addition, the effect of APOA5 gene polymorphism on clinical status and other parameters was determined to vary depending on gender. A borderline association was found between APOA5 −1131T>C and type 2 diabetes mellitus (p=0.055). This polymorphism was found to be associated with obesity and it was observed that the APOA5 -1131C allele carriers had a reduced risk for obesity (p<0.05). Logistic regression analysis adjusted for age and gender indicated that APOA5 -1131C allele carriage had a protective effect against obesity in the study group (odds ratio: 0.48, 95% confidence interval: 0.29-0.78; p=0.003). Conclusion: In this study, the APOA5 gene polymorphism, one of the genetic factors that may lead to atherosclerotic CAD, was found to be associated with obesity. The APOA5 −1131T>C polymorphism was associated with important risk factors for CAD, obesity and serum lipid levels. |
4. | Role of polymorphisms of the endothelial nitric oxide synthase gene in predicting slow-flow phenomenon after primary percutaneous coronary intervention Reza Kiani, Sanam Alilou, Shirin Rafatnia, Yasaman Taslimi, Sima Habibzadeh, Safoora Gharibzadeh, Ata Firouzi, Shahin Rahim, Ali Zahedmehr, Farzaneh Mehrvarz, Mehrdad Moghadam Ahari, Parham Sadeghipour PMID: 32633262 doi: 10.5543/tkda.2020.53849 Pages 472 - 483 Objective: The aim of the present study was to examine the association between 2 polymorphisms of the endothelial nitric oxide (eNOS) gene (-786T>C and +894G>T) and the no-reflow/slow-flow phenomenon in post-primary percutaneous coronary intervention (PPCI) patients. Methods: A total of 103 post-PPCI patients were enrolled. Coronary no-reflow phenomenon was defined as a Thrombolysis in Myocardial Infarction (TIMI) flow grade 0–1 and coronary slow-flow phenomenon (CSFP) was defined as a TIMI flow grade ≤2. Results: Due to the small number of post-PPCI patients with the no-reflow phenomenon (n=4), the primary comparison was made between CSFP (n=20) and normal flow (n=83) groups. There was a greater frequency of CSFP among carriers of the –786C allele of the eNOS –786T>C polymorphism (odds ratio [OR]: 3.90; 95% confidence interval [CI]: 0.87–17.45; p=0.07). However, no such association was detected between the +894T allele of the eNOS +894G>T and CSFP (OR: 0.92; 95% CI: 0.21–3.98; p=0.91). In the adjusted analysis, the -786T>C polymorphism did not reach statistical significance. Conclusion: There was no significant association between CSFP and 2 of the most common polymorphisms of the eNOS gene in post-PPCI patients. |
5. | The effects of genetic polymorphisms and diabetes mellitus on the development of peripheral artery disease Zafer Yalım, Serap Tutgun Onrat, Sümeyra Alan, Mustafa Aldemir, Alaettin Avşar, İsmet Doğan, Ersel Onrat PMID: 32633259 doi: 10.5543/tkda.2020.15686 Pages 484 - 493 Objective: Peripheral artery disease (PAD) is a condition caused by the narrowing of limb arteries due to atherosclerosis. In recent years, polymorphisms in a number of genes have been shown to contribute to the risk of PAD development. However, whether the contribution of these inheritable factors is independent of traditional cardiovascular risk factors remains unclear. This study was an investigation of the effects of diabetes mellitus (DM) and genetic background, examined singly and together, on the pathogenesis of PAD. Methods: The effects of the factor V Leiden (G1691A), factor V H1299R, prothrombin G20210A, factor XIII V34L, B-fibrinogen -455 G>A, PAI-1 4G/5G, HPA1, MTHFR C677T, MTHFR A1298C, ACE I/D, APO B R3500Q, and APOE polymorphisms were evaluated using a cardiovascular disease strip assay (CVD StripAssay). Two groups were created: 100 patients with PAD (50 with DM, 50 without DM) and 60 controls without PAD (30 with DM, 30 without DM). Results: There was a significantly greater presence of the MTHFR A1298C and PAI 4G/5G homozygous polymorphisms in the PAD patients compared with the control group (p=0.035, p=0.004, respectively). There were no significant associations between the other genotypes and polymorphism frequencies. In the presence of DM, the PAI-1 4G/5G homozygous polymorphism was linked to the formation of PAD (p=0.021). Regression analysis indicated that the PAI-1 4G/5G gene homozygous polymorphism demonstrated a 17.1 times greater risk for DM with PAD [95% confidence interval (CI): 2.113-138.660; p=0.008] and the MTHFR A1298C homozygous polymorphism demonstrated a 316.6 times greater risk (95% CI: 10.763-9315.342; p<0.001) for the possibility of DM with PAD. Conclusion: The MTHFR A1298C and PAI 4G/5G homozygous polymorphisms may be associated with the development of PAD. The presence of the PAI 4G/5G homozygous polymorphism with DM was a powerful predictor for the development of PAD. |
6. | Perceived stress level is associated with coronary artery disease severity in patients with ST-segment elevation myocardial infarction Serkan Kahraman, Fatma Cam Kahraman, Hicaz Zencirkiran Agus, Ali Kemal Kalkan, Fatih Uzun, Muammer Karakayalı, Mehmet Altunova, Samet Sevinç, Ali Rıza Demir, Emre Yılmaz, Mehmet Ertürk PMID: 32633260 doi: 10.5543/tkda.2020.30020 Pages 494 - 503 Objective: Stress is known to be a significant risk factor for coronary atherosclerosis and adverse cardiovascular events; however, the stress-related coronary atherosclerotic burden has not yet been investigated. The aim of this study was to investigate the relationship between the Perceived Stress Scale (PSS) and the SYNTAX scores in patients with ST-segment elevation myocardial infarction (STEMI). Methods: A total of 440 patients with STEMI were prospectively enrolled and divided into 2 groups according to the PSS score with a ROC curve analysis cut-off value of 17.5. In all, 361 patients with a low PSS score were categorized as Group 1 and 79 patients with a high PSS score were categorized as Group 2. Results: The SYNTAX score [Group 1, 16.0 (10.0–22.5); Group 2, 22.5 (15.0–25.5); p<0.001] and the SYNTAX score II were significantly higher in Group 2 [Group 1, 24.8 (19.0–32.6); Group 2, 30.9 (22.3–38.9); p<0.001]. Spearman analysis demonstrated that the PSS score was associated with the SYNTAX score (r=0.153; p=0.001) and the SYNTAX score II (r=0.216; p<0.001). Additionally, the PSS (odds ratio: 2.434, confidence interval: 1.446-4.096; p=0.001) was determined to be an independent predictor of a moderate-to-high SYNTAX score. The PSS score of patients with in-hospital mortality was also higher than those who survived [15 (10–20); 9 (4–16), respectively; p=0.007]. Conclusion: Stress appears to accelerate the coronary atherosclerotic process and the associated burden. An increased stress level was found to be an independent predictor of a high SYNTAX score. |
7. | Low cardiac output syndrome score to evaluate postoperative cardiac surgery patients in a pediatric intensive care unit Nagehan Aslan, Dinçer Yıldızdaş, Uğur Göçen, Sevcan Erdem, Fadli Demir, Ahmet Yontem, Özden Özgür Horoz, Yaşar Sertdemir PMID: 32633258 doi: 10.5543/tkda.2020.13844 Pages 504 - 513 Objective: There is no clear consensus regarding the definition of low cardiac output syndrome (LCOS) or the follow-up of this patient group. Given this lack of a clinical definition, the aim of this study was to use a LCOS score (LCOSs) similar to the low cardiac output score previously presented in the literature and evaluate the relationship between a high LCOSs and poor clinical outcome. Methods: A total of 54 patients were prospectively evaluated after cardiac surgery. The LCOSs was used to evaluate the deve-lopment of low cardiac output. Each parameter was scored as 1 point. The score was calculated every hour for 24 hours postoperatively and the highest score was recorded as the peak score (pLOCSs). The LOCSs at the time of admission to the pediatric intensive care unit, at the 4th, 8th, and 16th hour were recorded and a cumulative score (cLOCSs) score was calculated. Results: The mean age of the patients was 49.40±53.15 months and 24.07% had LOCS. In the group with LCOS, the cLOCSs, vasoactive-ınotropic score (VIS), lactate mean, aortic clamp time, and the total cardiopulmonary bypass time were significantly higher. In this study, a significant and positive correlation was found between the cLOCSs and pLOCSs and the length of hospital stay, length of stay in the pediatric intensive care unit, VIS, lactate mean, and aortic clamp duration. Conclusion: The objective of this study was to draw attention to the potential use of a common language in the care of critical pediatric patients undergoing cardiac surgery with a previously defined scoring method that includes parameters indicating poor perfusion in the patient. |
REVIEW | |
8. | Cardiac scintigraphy-centered diagnostic process in transthyretin cardiac amyloidosis Ilknur Ak Sivrikoz, Yüksel Çavuşoğlu PMID: 32633270 doi: 10.5543/tkda.2020.90914 Pages 514 - 521 Cardiac amyloidosis (CA) is a progressive infiltrative cardiomyopathy. Amyloid fibrils in the form of misfolded endogenous proteins accumulate in the heart, as well as the kidneys, liver, and gastrointestinal tract. The most common forms of CA are transthyretin (TTR) and immunoglobulin light chain amyloidosis (AL). CA has long been thought to be a rare disease. However, recent reports have suggested that 13% of heart failure patients with a preserved ejection fraction and 16% of advanced-age patients with severe aortic stenosis have TTR-CA. Patients with TTR-CA have a poor prognosis, with a median survival of 2–4 years; however, early diagnosis and novel therapeutic options have been shown to significantly improve the prognosis. Scintigraphy using bone isotopes is considered a highly reliable and easy-to-use method in the diagnosis of TTR-CA. This is a review of the role of scintigraphic imaging with technetium-99m- labeled bisphosphonates in the diagnostic work-up process of TTR-CA and the applicable protocols. |
HOW TO? | |
9. | How to prevent cardiac implantable electronic device infections? Yalçın Velibey, Mutlu Şeyda Öcalmaz PMID: 32633267 doi: 10.5543/tkda.2020.79829 Pages 522 - 530 Abstract | |
CASE REPORT | |
10. | Monozygotic twins with familial hypercholesterolemia and high lipoprotein(a) levels leading to identical cardiovascular outcomes: Case report and review of the literature Meral Kayıkçıoğlu, Hakan Gökalp Uzun, Aslı Tetik Vardarlı, Lale Tokgözoğlu PMID: 32633265 doi: 10.5543/tkda.2020.62185 Pages 531 - 538 Homozygous familial hypercholesterolemia (HoFH) is a rare, autosomal dominant disease that leads to premature cardiovascular disease (CVD). Since monozygotic twins share the intrauterine environment and have the same age and gene profile, they could represent a very special resource for the investigation of the causes and the natural course of FH. This report is a description of 36-year-old monozygotic twin brothers with almost identical early coronary artery involvement due to FH concomitant with high lipoprotein(a) (Lpa) levels and a review of the literature. Sequence analysis revealed that the twins were homozygous for the LDLR c.1060+10G>A (rs12710260) mutation and heterozygous for the LDLR c.542C>T (rs557344672) mutations. Both were also homozygous for the c.1060+7T>C (rs2738442) and c.1586+53A>G (rs1569372) mutations in the LDLR gene as well as c.4265A>T (rs568413) mutations in the APOB gene. In the literature, there are 7 twin cases with reported FH, but none with high Lpa levels. The HoFH twins in this case report had lower low-density lipoprotein (LDL) cholesterol levels than expected (before treatment 204 and 223 mg/dL), with almost identical coronary involvement. Both had an extremely high Lpa level (308 and 272 nmol/L) with a very low coronary calcium score (16 AU) and a good response to statins (>60%). There was a history of the first CVD event occurring at nearly the same age (32–34 years) in the family. This could be an important aspect of FH families as a result of the similar timing of cumulative LDL exposure exceeding the threshold of CVD events. In conclusion, this first report of monozygotic HoFH twins with elevated Lpa levels and almost identical early coronary artery involvement at the same age provides evidence to substantiate the hypothesis of lifetime cholesterol burden/exposure. |
11. | Complementary role of different imaging modalities in the diagnosis of concurrent obstructive aortic and mitral prosthetic valve thrombosis Ahmet Güner, Mehmet Aytürk, Semih Kalkan, Abdülkadir Uslu, Mehmet Özkan PMID: 32633263 doi: 10.5543/tkda.2019.55013 Pages 539 - 544 Prosthetic valve thrombosis (PVT) is a life-threatening valve dysfunction. In asymptomatic cases, as well as certain symptomatic patients with PVT, the results of the first-line imaging tool, transthoracic echocardiography, may be inconclusive in terms of illustrating the thrombus, which is necessary in order to select the proper treatment option. Hence, a differential diagnosis based on clinical presentation may be challenging, and multimodality imaging, including echocardiography, cine fluoroscopy, and cardiac computed tomography, is usually required to distinguish between PVT and other prosthesis-related pathologies, such as pannus, vegetation, and prosthesis-patient mismatch. |
12. | Development of acute severe right heart failure after transcatheter aortic valve implantation in patient with left ventricle assist device-acquired aortic regurgitation Zübeyde Bayram, Cem Doğan, Emre Gürcü, Cihangir Kaymaz, Nihal Özdemir PMID: 32633261 doi: 10.5543/tkda.2020.39132 Pages 545 - 551 A 58-year-old man with a left ventricular assist device (LVAD), which had been implanted 1 year earlier, presented with rest dyspnea. Moderate to severe aortic regurgitation (AR), pre-postcapillary pulmonary hypertension, modarete right ventricular (RV) failure, and low cardiac output were observed at presentation. Transcatheter aortic valve implantation (TAVI) was performed to treat the AR and a self-expandable aortic valve was implanted. Within minutes, hypotension, RV and inferior vena cava dilatation, and left atrial (LA) and left ventricular (LV) collapse occurred and persisted despite LVAD speed reduction. It was observed that severe RV failure had developed and venoarterial extracorporeal membrane oxygenation (VA-ECMO) was applied. Following VA-ECMO treatment, the RV dimensions decreased, and the LA and LV dimensions began to increase, as well as the LVAD flow. Weaning from VA-ECMO was unsuccessful and exitus occurred on the fifth day after TAVI secondary to RV failure. It was surmised that the decrease in blood circulation from the aorta to the LV after treatment of severe AR with TAVI caused an acute increase in the cardiac output and the RV preload. The acute increase in the RV preload led to acute severe right heart failure. It is necessary to prepare the RV to compete with an acute increase in preload before TAVI even when there is only modarete RV failure. |
CASE IMAGE | |
13. | Electrogram-guided mapping after visualization of the tricuspid valve annulus for His bundle pacing Serdar Bozyel, Kivanc Yalin, Tumer Erdem Guler, Tolga Aksu PMID: 32633257 doi: 10.5543/tkda.2020.07755 Page 552 Abstract | English Full Text |
14. | Twenty-seven-year durability of St. Jude Medical Biocor bovine bioprosthesis in mitral position Semih Kalkan, Ahmet Güner, Emrah Bayam, Macit Kalcik, Mehmet Ozkan PMID: 32633269 doi: 10.5543/tkda.2020.91954 Page 553 Abstract | English Full Text |
OTHER ARTICLES | |
15. | Comment on cardiology publications Ertan Ural Page 554 Abstract | |
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