Role of the Polymorphisms of the Endothelial Nitric Oxide Synthase Gene in Predicting the Slow Flow Phenomenon After Primary Percutaneous Coronary Intervention [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. Ahead of Print: TKDA-53849 | DOI: 10.5543/tkda.2020.53849

Role of the Polymorphisms of the Endothelial Nitric Oxide Synthase Gene in Predicting the Slow Flow Phenomenon After Primary Percutaneous Coronary Intervention

Reza Kiani1, Sanam Alilou2, Shirin Rafatnia2, yasaman taslimi3, Sima Habibzadeh3, Safoora Gharibzadeh4, ata firouzi1, Shahin Rahim1, Ali Zahedmehr1, Farzaneh Mehrvarz1, Mehrdad Moghadam Ahari1, Parham Sadeghipour1
1Cardiovascular Intervention Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran
2Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran
4Department of Epidemiology and Biostatistics, Pasteur Institute of Iran, Tehran, Iran


BACKGROUND
In the present study on post-primary percutaneous coronary intervention (PPCI) patients, we aimed to study the association between two polymorphisms of the endothelial nitric oxide (eNOS) gene (-786T>C and +894G>T) and the no-reflow/slow flow phenomenon.

METHODS
A total of 103 post-PPCI patients were enrolled. The coronary no-reflow phenomenon was defined as a thrombolysis in myocardial infarction (TIMI) flow grade 0–1, and the coronary slow-flow phenomenon (CSFP) was defined as a TIMI flow grade ≤ 2.

RESULTS
Due to the small number of post-PPCI patients complicated by the no-reflow phenomenon (n = 4), the main comparison was made between the CSFP (n = 20) and normal-flow (n = 83) groups. Carriers of the –786C allele of the eNOS –786T>C polymorphism showed a trend of a higher frequency of the CSFP (OR: 3.90, 95% CI: 0.87 to 17.45; P = 0.07). However, no such association was detected for the +894T allele of the eNOS +894G>T and the CSFP (OR: 0.92, 95% CI: 0.21 to 3.98; P = 0.91). In the adjusted analysis, the -786T>C polymorphism did not reach statistical significance after adjustments.

CONCLUSIONS
We found no significant association in our post-PPCI patients between the CSFP and 2 of the most common polymorphisms of the eNOS gene.

Keywords: ST-segment elevation myocardial infarction, Primary percutaneous coronary intervention, No-reflow, Slow Flow, Gene polymorphism, Endothelial nitric oxide

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Corresponding Author: Parham Sadeghipour, Iran
© Copyright 2020 Archives of the Turkish Society of Cardiology
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