ISSN 1016-5169 | E-ISSN 1308-4488
The effects of Curcumin on mechanical functions and cardiac contractility in isolated rat hearts [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. Ahead of Print: TKDA-69765 | DOI: 10.5543/tkda.2022.69765

The effects of Curcumin on mechanical functions and cardiac contractility in isolated rat hearts

Özden Kutlay1, Bilgin Kaygısız2, Arzu Keskin Aktan1
1Afyonkarahisar Health Sciences University, Faculty of Medicine, Department of Physiology, Afyonkarahisar, Turkey
2Department of Pharmacology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Türkiye

Objectıve: Curcumin is a bioactive compound that has well-known pharmacological activities. Numerous studies appeared to curcumin exerts potential cardiovascular benefits through various mechanisms. The present study aims to discuss different concentrations of curcumin’s impact on mechanical functions and cardiac contractility in isolated perfused rat hearts.

The hearts were isolated under sodium thiopental (50 mg/kg) anesthesia and perfused with a modified Krebs-Henseleit solution (mK-Hs). After stabilization, curcumin was applied in concentrations of 0.1, 1, and 10 µM. In isolated rat hearts, indexes of + dP / dt max, LVDP, and LVEDP were evaluated for cardiac contractility and ventricular function.
All curcumin concentrations reduced +dP/dtmax and LVDP.. Ten µM curcumin also significantly decreased heart rate. Curcumin (1 and 10 µM ) increased LVEDP and reduced MAP amplitude with a concomitant increase in MAP duration. Curcumin at all concentrations did not affect dMAPdtmax and dMAPdtmin.

Conclusıon: Our results might suggest that curcumin at higher concentrations (≥ 1 µM) increases LVEDP with a negative chronotropic effect and decreases MAP amplitude with an increase in MAP duration. There is sufficient evidence from this study that Curcumin possesses an adverse inotropic action. Different disease models should support the pathophysiological role of Curcumin on cardiac contraction.

Keywords: Animal model, autonomic nervous system, curcumin, heart rate, cardiac contractility, left ventricular end-diastolic pressure, ısolated rat heart, hemodynamics

How to cite this article

Corresponding Author: Özden Kutlay, Türkiye
Manuscript Language: English

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