ISSN 1016-5169 | E-ISSN 1308-4488
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The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2023; 51(4): 235-240 | DOI: 10.5543/tkda.2022.69765

The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts

Özden Kutlay1, Bilgin Kaygısız2, Arzu Keskin Aktan1
1Afyonkarahisar Health Sciences University, Faculty of Medicine, Department of Physiology, Afyonkarahisar, Türkiye
2Department of Pharmacology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Türkiye


OBJECTIVE
Curcumin is a bioactive compound that has well-known pharmacological activities. Numerous studies have shown that curcumin provides potential cardiovascular benefits through a variety of mechanisms.The present study aims to discuss different concentrations of curcumin’s impact on mechanical functions and cardiac contractility in isolated perfused rat hearts.


METHODS
The hearts were isolated under sodium thiopental (50 mg/kg) anesthesia and perfused with a modified Krebs-Henseleit solution (mK-Hs). After stabilization, curcumin was applied in concentrations of 0.1, 1, and 10 µM. In isolated rat hearts, indexes of + dP / dt max, LVDP, MAP, and LVEDP were evaluated for cardiac contractility and ventricular function.


RESULTS
All curcumin concentrations reduced +dP/dtmax and LVDP. Ten µM curcumin also significantly decreased heart rate. Curcumin (1 and 10 µM) increased LVEDP and reduced MAP amplitude with a concomitant increase in MAP duration. Curcumin at all concentrations did not affect dMAPdtmax and dMAPdtmin.


CONCLUSION
Our results might suggest that curcumin at higher concentrations (≥ 1 µM) increases LVEDP with a negative chronotropic effect and decreases MAP amplitude with an increase in MAP duration. There is sufficient evidence from this study that Curcumin possesses an adverse inotropic action. Different disease models should support the pathophysiological role of Curcumin on cardiac contraction.

Keywords: Cardiac contractility, curcumin, heart rate, isolated rat heart, left ventricular end-diastolic pressure

How to cite this article
Özden Kutlay, Bilgin Kaygısız, Arzu Keskin Aktan. The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts. Turk Kardiyol Dern Ars. 2023; 51(4): 235-240

Corresponding Author: Özden Kutlay, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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