ISSN 1016-5169 | E-ISSN 1308-4488
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Relationship Between Sclerostin Levels and Coronary Artery Calcification and Plaque Composition [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2023; 51(4): 266-273 | DOI: 10.5543/tkda.2023.61595

Relationship Between Sclerostin Levels and Coronary Artery Calcification and Plaque Composition

Yasin Yüksel1, Cennet Yıldız2, Ibrahim Taskın Rakıcı3
1Department of Cardiology, Istanbul Training and Research Center, Istanbul, Türkiye
2Department of Cardiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Türkiye
3Department of Radiology, Istanbul Training and Research Hospital, Istanbul, Türkiye


OBJECTIVE
The primary function of sclerostin is the regulation of bone metabolism. Research investigating the cardiovascular effects of sclerostin had conflicting results. We aimed to study serum sclerostin levels in coronary artery plaque types.


METHODS
Coronary calcium scores of 175 patients were evaluated. Patients with normal coronary arteries and calcium score of greater than zero constituted control (n = 47) and study groups (n = 83), respectively. Patients’ plaques were further categorized as non-calcified plaque, calcified plaque, or mixed plaque (n = 45, n = 40, and n = 43, respectively).


RESULTS
The study group had increased serum sclerostin levels than that of controls. Moreover, sclerostin levels were significantly higher in patients with calcified or mixed plaques compared to those without plaque or non-calcified plaque (median 248.5, 60.7-790.4) pg/mL and 1085.8 (185.8-3902.2) pg/mL versus 68.7 (34.0-141.3) pg/mL, and 67.7 (48.6-94.9) pg/mL, P < 0.001, respectively). Sclerostin showed a high correlation with coronary calcium scores (r = 0.95, P < 0.001). Serum sclerostin concentration of 106.27 pg/mL had 97.5% sensitivity and 67.4% specificity for the prediction of calcific plaque, whereas the level of 308.55 pg/mL had 95.3% sensitivity and 90.9% specificity for the prediction of mixed plaque. Coronary calcium scores, serum sclerostin, and C-reactive protein levels were significant predictors of 1-year major adverse cardiac events.


CONCLUSIONS
Increased serum sclerostin level is a marker of coronary atherosclerosis burden and has a value for the prediction of 1-year major adverse cardiac events.

Keywords: Coronary calcifi, cation, coronary computed tomography angiography, sclerostin

How to cite this article
Yasin Yüksel, Cennet Yıldız, Ibrahim Taskın Rakıcı. Relationship Between Sclerostin Levels and Coronary Artery Calcification and Plaque Composition. Turk Kardiyol Dern Ars. 2023; 51(4): 266-273

Corresponding Author: Cennet Yıldız, Türkiye
Manuscript Language: English


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Journal Citation Indicator: 0.18
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