Turk Kardiyol Dern Ars. 2005; 33(5): 304-308

Platypnea-orthodeoxia syndrome and its transcatheter treatment

Hürkan Kurşaklıoğlu¹, Atila İyisoy¹

Platypnea-orthodeoxia is characterized by dyspnea and hypoxia occurring with a change to a sitting or standing posture from a recumbent position. About 150 cases have been reported since the first description of the condition in 1949. The majority of cases are older individuals having an intracardiac right-to-left shunt. This syndrome can also be associated with lung and liver diseases, drug intoxication, and pericardial diseases. Most of the affected patients with an intracardiac shunt present with a patent foramen ovale. Recently, there have been reports of successful management of platypnea-orthodeoxia syndrome by transcatheter closure of the patent foramen ovale. In this review, characteristic features of, and diagnostic methods for platypnea-orthodeoxia syndrome are summarized together with recent advances in its treatment.

Keywords: Anoxemia; cardiovascular abnormalities; dyspnea/etiology; heart catheterization; heart septal defects, atrial; oxygen/blood; pneumonectomy; posture; syndrome

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