Effect of Nitrovasodilators on Nitric oxide-cyclic GMP Pathway during Cardiopulmonary Bypass

This study, aimed to evaluate the effect of nitrovasodilators on the pathway of nitric oxideguanosine monophosphate (cGMP) administrated preoperatively to patients under going coronary artery bypass grafting under cardiopulmonary bypass (CPB). Of 30 cases who underwent coronary artery bypass grafting, 15 were administrated isosorbieder dinitrate preoperatively, and 15 cases with out angina pectorisa were weaned from nitrated drugs and remained as a control group. Before and after CPB, plasma cGMP levels of blood samples taken from coronary sinus were measured. The two groups disclosed no statistically significant difference between mean data regarding age, sex, weight, aortic cross clamp time, and CPB time.
RESULTS
In the nitrate group, the mean plasma cGMP !eve! before CPB was measured as 5.76 ± 0.57 pmol/ml, and that of the control group was measured as 2.78±0.3 pmol/ml, while after CPB the mean plasma cGMP !eve! was 7.77±0.30 prnol/mJ in the nitrate group and 3.66±0.20 in the control group (pKeywords: Nitric oxide cy lic-GMP cardiopulmonary by-pass, nitrovasodilators