Archives of the Turkish Society of Cardiology
Thrombophilic Gene Mutation Analysis of Coronary Artery Ectasia [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. Ahead of Print: TKDA-99789 | DOI: 10.5543/tkda.2019.99789

Thrombophilic Gene Mutation Analysis of Coronary Artery Ectasia

Zafer Yalım1, Serap Tutgun Onrat2, volkan emren3, İbrahim Etem Dural4, Alaettin Avsar1, Ersel Onrat1
1Departments Of Cardiology, Afyonkarahisar Health Sciences University, Afyon, Turkey
2Departments Of Medical Genetics, Afyonkarahisar Health Sciences University, Afyon, Turkey
3Departments Of Cardiology, İzmir Katip Çelebi University, İzmir, Turkey
4Departments Of Cardiology, Sandıklı State Hospital, Afyon, Turkey


OBJECTIVES
Coronary artery ectasia (CAE) is defined as localized or diffuse dilatation of the coronary artery lumen exceeding the diameter of adjacent healthy reference segments by 1.5 times. The etiology of coronary artery ectasia is still unknown, but the most likely cause is atherosclerosis. In this study, we aimed to evaluate some gene polymorphisms that are thought to be effective in the development of coronary atherosclerosis and have been shown to cause thrombophilia in CEA patients.


METHODS
In our study Factor V Leiden (G1691A), Factor V H1299R, Prothrombin G20210A, Factor XIII V34L, B-Fibrinogen -455 G>A, PAI-1 4G/5G, MTHFR C677T, and MTHFR A1298C polymorphisms were evaluated in 66 patients with CAE and 32 individuals with normal coronary artery group.


RESULTS
Comparison of the CAE and control groups revealed that clinical features and the frequency of polymorphism in thrombophilic genes (Factor V Leiden (G1691A Factor V H1299R, Prothrombin G20210A, Factor XIII V34L, Beta-Fibrinojen -455 G>A, PAI-1 4G/5G, MTHFR C677T and MTHFR A1298C) were similar in both groups. However, when the groups whether heterozygous and / or homozygous polymorphism were compared, it was found that the CAE group had significantly higher thrombophilic genes polymorphism (p: 0.023).


CONCLUSION
Thrombophilic gene polymorphism may be associated to formation and clinical presentation in CAE.

Keywords: Coronary artery ectasia, gen polymorphism, thrombophilia

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Corresponding Author: Zafer Yalım, Türkiye
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