ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Cyclophilin A and D Levels in Acute Coronary Syndrome and Their Relationship with Cardiovascular Risk Factors [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2023; 51(8): 531-536 | DOI: 10.5543/tkda.2023.98302

Cyclophilin A and D Levels in Acute Coronary Syndrome and Their Relationship with Cardiovascular Risk Factors

Abdulkadir Tekin1, Murat Can1, Mustafa Ozan Çakır2, Ayça Görkem Mungan1, Berrak Güven1
1Department of Biochemistry, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Türkiye
2Department of Cardiology, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Türkiye


OBJECTIVE
Our objective was to evaluate cyclophilin levels in patients with acute coronary syndrome (ACS) and their association with the clinical characteristics of these patients.


METHODS
We enrolled 150 patients with ACS (n=75 ST-elevation myocardial infarction [STEMI], n = 75 non-ST-elevation myocardial infarction [NSTEMI]). For comparison, 25 healthy volunteers were included in the study. Levels of cyclophilin A, cyclophilin D, and C-reactive protein (CRP) were measured in both the acute myocardial infarction (AMI) groups and the healthy group. We examined the effects of cardiovascular risk factors, including diabetes mellitus, hypertension, dyslipidemia, age, gender, and smoking on these parameters.


RESULTS
Cyclophilin A levels were significantly lower in the STEMI group, while cyclophilin D and CRP levels were significantly higher in all AMI groups (P < 0.05). A negative correlation existed between cyclophilin A and troponin T and CK-MB (respectively r = -0.287, P < 0.001; r = -0.231, P = 0.005). However, there was no correlation between cyclophilin D and the cardiac markers. A positive correlation was observed between cyclophilin D and CRP (r = 0.219, P = 0.004). Cyclophilin A was associated with hypertension, whereas cyclophilin D was associated with the female gender and dyslipidemia (P < 0.05).


CONCLUSION
Our findings suggest that a decrease in cyclophilin A indicates a more severe disease in STEMI and an increase in cyclophilin D in both STEMI and NSTEMI may be valuable markers. Therefore, further detailed studies are warranted to monitor their changes and interactions in ACS patients.

Keywords: Acute myocardial infarction, cyclophilin A, cyclophilin D

How to cite this article
Abdulkadir Tekin, Murat Can, Mustafa Ozan Çakır, Ayça Görkem Mungan, Berrak Güven. Cyclophilin A and D Levels in Acute Coronary Syndrome and Their Relationship with Cardiovascular Risk Factors. Turk Kardiyol Dern Ars. 2023; 51(8): 531-536

Corresponding Author: Abdulkadir Tekin
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

Quick Search



Copyright © 2024 Archives of the Turkish Society of Cardiology



Kare Publishing is a subsidiary of Kare Media.