Turk Kardiyol Dern Ars. 2020; 48(2): 103-108 | DOI: 10.5543/tkda.2019.96613
The need for permanent pacemaker after restoration of conduction following atrioventricular block: a retrospective cohort study
, Sajad Ahmadzadeh2
, Seyedeh Hamideh Mortazavi2
, Saeed Sadeghian1
, Ali Vasheghani Farahani1
, Kaveh Hosseini2
, Arash Jalali2
, Keyvan Ghasemi2
, Mehdi Mehrani2
, Masih Tajdini21
Department of Electrophysiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran2
Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
OBJECTIVE A permanent pacemaker (PPM) is necessary for patients with a symptomatic third-degree or advanced second-degree atrioventricular (AV) block. An AV block due to medication use can often be reversed; however, subsequent relapse can occur and necessitate subsequent PPM implantation. The aim of this study was to explore the course and prognosis of patients with an AV block.
METHODS This historical cohort study was conducted between January 2013 and June 2018. A total of 1900 patient records were analyzed and 1123 subjects with an AV block on admission were enrolled. The patients were categorized into 2 groups: Group 1 comprised patients with an AV block due to medication use (n=316, 28%) and Group 2 included patients with an AV block caused by other etiologies (n=807, 72%). Data of the cause of AV block, recurrence, and PPM implantation were analyzed. Patients in both groups who did not require a PPM during the index admission were followed up regarding subsequent implantation of a PPM.
RESULTS AV conduction was recovered in 38 (12%) patients in Group 1 and 48 (6%) patients in Group 2 during the index hospitalization. However, recurrence of the AV block was observed in 18% of Group 1 patients and 40% of Group 2 patients. Only 25 patients in each group (4.5% of the whole study population) remained PPM-free during a median 3-year follow-up period.
CONCLUSION The study findings suggest that drug-induced AV blocks may not be as benign as previously thought. The high relapse rate indicates that watchful follow-up may be required despite discontinuation of the responsible medication and that consideration of earlier PPM implantation in cases of early recurrence may be warranted.
Atrioventricular block, drug-induced atrioventricular block; permanent pacemaker.
How to cite this article
Ali Bozorgi, Sajad Ahmadzadeh, Seyedeh Hamideh Mortazavi, Saeed Sadeghian, Ali Vasheghani Farahani, Kaveh Hosseini, Arash Jalali, Keyvan Ghasemi, Mehdi Mehrani, Masih Tajdini. The need for permanent pacemaker after restoration of conduction following atrioventricular block: a retrospective cohort study. Turk Kardiyol Dern Ars. 2020; 48(2): 103-108
Corresponding Author: Masih Tajdini, Iran