Archives of the Turkish Society of Cardiology
Comparison of Martin and Friedewald equation for estimated LDL-C in adults [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2021; 49(8): 619-626 | DOI: 10.5543/tkda.2021.90446

Comparison of Martin and Friedewald equation for estimated LDL-C in adults

Medine Alpdemir, Mehmet Fatih Alpdemir
Clinical Biochemistry Laboratory, Balıkesir State Hospital, Balıkesir, Turkey

In this study, we aimed to compare the directly measured low-density lipoprotein cholesterol (LDL-C), Friedewald, and a new Martin LDL-C formula in the Turkish adult population.

A total of 1,558 patients between the ages of 18 and 65 years with a triglyceride level of <400 mg/dL were included in this study. Serum lipid profiles of all the patients were measured with Cobas 6000 c501 (Roche Diagnostic), and LDL-C concentrations were measured by a homogeneous direct method using reagents. [TC- (HDL-C+(TG/5)] and Martin [TC- (HDL-C+TG / new adjustable factor)] formulas were used to estimate LDL-C.

The average age of the patients was 52.7±12.3 years. Of the 1,558 patients, 56% were women and 44% were men. The d-LDL-C, F-LDL-C, and M-LDL-C concentrations in all the patients were 148.6±39.8 mg/dL, 123.9±38.7 mg/dL, and 133.4±35.9 mg/dL, respectively. The mean difference between F-LDL-C and M-LDL-C concentrations according to d-LDL-C was 24.6±10.7 and 15.10±10.3, respectively. For comparing the scatter blot plot [estimated LDL-C(x) and d-LDL-C(y)] were calculated by the equations y=1.1665x+0 for Friedewald and y=1.1667x+0 for Martin. When compared to the d-LDL-C concentration, both the Friedewald and Martin formulas showed a strong correlation (r=0.963, r=0.968, respectively). The new adjustable factor mean of the Martin formula was 6.1±0.9.

In our study, the Martin formula showed a relatively better separation. Although there was a strong correlation between the formulas and d-LDL-C, there was a negative bias for the two formulas. These formulas show a lower risk in the determination of the risk of coronary heart disease and in the planning of treatment strategies.

Keywords: Friedewald formula, Martin formula, LDL cholesterol, Direct LDL measurement, LDL cholesterol estimation.

How to cite this article
Medine Alpdemir, Mehmet Fatih Alpdemir. Comparison of Martin and Friedewald equation for estimated LDL-C in adults. Turk Kardiyol Dern Ars. 2021; 49(8): 619-626

Corresponding Author: Medine Alpdemir, Türkiye
Manuscript Language: English
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