ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Change in Aortic Stiffness with Nitroglycerin and Extent of Coronary Artery Disease [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2002; 30(8): 493-497

Change in Aortic Stiffness with Nitroglycerin and Extent of Coronary Artery Disease

Şevket GÖRGÜLÜ1, Mehmet EREN1, Seden ÇELİK1, Sacit CİNSOY1, Bahadır DAĞDEVİREN1, Nevzat USLU1, Orhan ÖZER1, Bülent UZUNLAR1, Burak TANGÜREK1, Tuna TEZEL1

The main objective of this study was to investigate the extent of coro nary artery disease by using the effect of nitroglycerin on aortic stiffness. Two study g roups were composed according to coronary angiographic results. 21 patients having single vessel disease and 22 patients multivessel disease. Pulse pressure, aortic diameter change, aortic strain and distensibility were used as aortic sti ffness parameters. Antianginal medications were withheld 48 hours before the study.The patients were allowed to use sublingual nitroglycerin as necessary, but caution was taken that no nitroglycerin medication was performed within 3 hours of its adıninistration . Echocard iographic assessment was performed in all patien ts before and at least 5 ın inute s after intravenous nitroglycerin administration.
RESULTS
Nitroglycerin exerted an increase in aoıtic diameter change ( 1.1±0.5 versus 1.6±0.6 before and after nitroglycerin , respectively; p=0.002) and aortic strain (6±3.51 vs. 9±4 before and after nitroglycerin, respectively; p0.05). As compared to findings before nitroglycerin administration, the improvement of the elasticity properties of the aorta with nitroglycerin may be helpful to d eter ın ine the extent of coronary artery disease.

Keywords: Nitroglycerin, aortic stiffness, coronary artery disease

How to cite this article
Şevket GÖRGÜLÜ, Mehmet EREN, Seden ÇELİK, Sacit CİNSOY, Bahadır DAĞDEVİREN, Nevzat USLU, Orhan ÖZER, Bülent UZUNLAR, Burak TANGÜREK, Tuna TEZEL. Change in Aortic Stiffness with Nitroglycerin and Extent of Coronary Artery Disease. Turk Kardiyol Dern Ars. 2002; 30(8): 493-497
Manuscript Language: Turkish


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