ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
A Combination of Heart Rate-Corrected QT Interval and GRACE Risk Score Better Predict Early Mortality in Patients with Non-ST Segment Elevation Acute Coronary Syndrome [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2022; 50(5): 340-347 | DOI: 10.5543/tkda.2022.21198

A Combination of Heart Rate-Corrected QT Interval and GRACE Risk Score Better Predict Early Mortality in Patients with Non-ST Segment Elevation Acute Coronary Syndrome

Saadet Demirtas Inci1, Mustafa Agah Tekindal2, Meltem Altınsoy1, Nail Burak Özbeyaz1, Hamza Sunman1, Alperen Taş1, Sabiye Yılmaz3, Sebahat Tekeli Şengül4, Cihan Altın5, Hakan Güllü1
1Department of Cardiology, Health Sciences University, Dışkapı Yıldırım Beyazıd Training and Research Hospital, Ankara, Turkey
2Department of Biostatistics, İzmir Katip Çelebi University, İzmir, Turkey
3Department of Cardiology, Kütahya Health Sciences University, Kütahya, Turke
4Department of Cardiology, Ankara Training and Research Hospital, Ankara, Turkey
5Department of Cardiology, İzmir University of Economics Medical Park Hospital, İzmir, Turkey


OBJECTIVE
This study aimed to evaluate whether the addition of heart rate-corrected QT inter-val prolongation to the Global Registry of Acute Coronary Events risk score improves the predictive value for early mortality in patients with non-ST segment elevation acute coronary syndrome.


METHODS
We retrospectively screened our database for consecutive non-ST-segment elevation acute coronary syndrome patients between January 2017 and July 2019. The demographic and clinical parameters were acquired via chart review. All electrocardiograms were reviewed by 2 physicians. QT interval was measured using the tangent method. Early mortality was defined as all-cause death observed during the hospital stay or within 30 days after discharge.


RESULTS
The final study population consisted of 283 patients, there were 17 early deaths. Ten of 59 patients with prolonged corrected QT intervals died (16.9%, P <.001). Both the Global Registry of Acute Coronary Events risk score (odds ratio: 1.032; 95% CI: 1.012-1.053; P =.002) and corrected QT interval (odds ratio: 1.026; 95% CI: 1.007-1.045; P = 0.007) independently
predicted early mortality. The area under value was 0.769 (95% CI: 0.674-0.863, P <.001) for the corrected QT interval and 0.780 (95% CI: 0.681-0.878; P <.001) for the Global Registry of Acute Coronary Events risk score alone. However, when the corrected QT interval and the Global Registry of Acute Coronary Events risk score were combined, it was found to be 0.808
(95% CI: 0.713-0.904, P <.001).


CONCLUSION
This study is the first to report that prolonged corrected QT and the Global Registry of Acute Coronary Events risk score independently predict early mortality and a combination of these 2 factors may improve the predictive value for early mortality in patients with ST-segment elevation acute coronary syndrome.

Keywords: Non-ST-segment elevation acute coronary syndrome, GRACE risk score, QTc interval

How to cite this article
Saadet Demirtas Inci, Mustafa Agah Tekindal, Meltem Altınsoy, Nail Burak Özbeyaz, Hamza Sunman, Alperen Taş, Sabiye Yılmaz, Sebahat Tekeli Şengül, Cihan Altın, Hakan Güllü. A Combination of Heart Rate-Corrected QT Interval and GRACE Risk Score Better Predict Early Mortality in Patients with Non-ST Segment Elevation Acute Coronary Syndrome. Turk Kardiyol Dern Ars. 2022; 50(5): 340-347

Corresponding Author: Saadet Demirtas Inci
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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