Archives of the Turkish Society of Cardiology
Admission Tpe interval predicts reperfusion success in STEMI patients treated with fibrinolytic agents [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2020; 48(1): 49-57 | DOI: 10.5543/tkda.2019.84789

Admission Tpe interval predicts reperfusion success in STEMI patients treated with fibrinolytic agents

Ali Çoner1, Sinan Akıncı1, Mehmet Hüsamettin Akküçük2, Cihan Altın3, Haldun Müderrisoğlu4
1Department of Cardiology, Başkent University Faculty of Medicine Alanya Application and Research Center, Alanya, Turkey
2Department of Emergency Medicine, Başkent University Faculty of Medicine Alanya Application and Research Center, Alanya, Turkey
3Department of Cardiology, Başkent University Faculty of Medicine İzmir Zübeyde Hanım Application and Research Center, İzmir, Turkey
4Department of Cardiology, Başkent University Faculty of Medicine, Ankara, Turkey


OBJECTIVE
Myocardial infarction is a leading cause of morbidity and mortality. Fibrinolytic administration is still a life-saving choice in ST-segment elevated myocardial infarction (STEMI), but the rate of successful reperfusion can be inconsistent. Failed reperfusion adds additional clinical risks to rescue percutaneous coronary intervention for STEMI patients. The interval between the peak of the T wave and the end of the T wave (Tpe) and the ratio of Tpe and a corrected measurement of the time from the start of the Q wave to the end of the T wave (Tpe/QTc ratio) are relatively new electrocardiogram (ECG) indices and have not yet been tested in STEMI patients treated with fibrinolytic agents.

METHODS
A total of 177 STEMI patients (mean age: 60.5±11.1 years; 138 men and 39 women) were enrolled in this retrospective study to evaluate ECG parameters. The Tpe interval and the Tpe/QTc ratio at baseline and at the 90th minute following the administration of fibrinolytic therapy were analyzed. The clinical and ECG findings of successful and failed reperfusion groups were compared.

RESULTS
Successful reperfusion was achieved in 119 patients (67.2%). The average Tpe interval on the admission ECG was shorter (91.7 vs. 100.9 milliseconds [ms]) (p<0.001) and shortened more in the successful reperfusion group (9.3 vs. 4.5 ms) (p<0.001). A cut-off value of 89.0 ms for the Tpe interval on the admission ECG was found to be related to reperfusion success with a sensitivity of 90.9%.

CONCLUSION
The Tpe interval was a predictor for reperfusion success in STEMI patients treated with fibrinolytic agents.

Keywords: Fibrinolytic administration, reperfusion success; ST-segment elevation myocardial infarction; Tpe interval.

How to cite this article
Ali Çoner, Sinan Akıncı, Mehmet Hüsamettin Akküçük, Cihan Altın, Haldun Müderrisoğlu. Admission Tpe interval predicts reperfusion success in STEMI patients treated with fibrinolytic agents. Turk Kardiyol Dern Ars. 2020; 48(1): 49-57

Corresponding Author: Ali Çoner, Türkiye
© Copyright 2020 Archives of the Turkish Society of Cardiology
LookUs & Online Makale