Archives of the Turkish Society of Cardiology
Assessment of regional left ventricular functions by strain and strain rate echocardiography in type II diabetes mellitus patients without microvascular complications [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2011; 39(5): 378-384 | DOI: 10.5543/tkda.2011.01490

Assessment of regional left ventricular functions by strain and strain rate echocardiography in type II diabetes mellitus patients without microvascular complications

M. Sertaç Alpaydın, Enbiya Aksakal, Mustafa Kemal Erol, Ziya Şimşek, Mahmut Açıkel, Şakir Arslan, Fuat Gündoğdu, Serdar Sevimli, Şule Karakelleoğlu
Department of Cardiology, Faculty of Medicine, Atatürk University, Erzurum, Turkey


OBJECTIVES
We evaluated regional left ventricular myocardial functions by strain (S) and strain rate (Sr) echocardiography in patients with type II diabetes mellitus (DM) without microvascular complications.

STUDY DESIGN
The study included 40 DM patients (20 women, 20 men; mean age 52.4±7.9 years) without microvascular complications, and 40 healthy controls (20 women, 20 men; mean age 52.8±10.1 years). Left ventricular functions were evaluated by conventional Doppler, tissue Doppler, and S-Sr echocardiography. Longitudinal peak systolic S and Sr were measured from the basal, mid and apical segments of the left ventricle walls. Patients with DM duration of >3 years (n=24) and receiving medical therapy for DM (n=30) were also evaluated.

RESULTS
Conventional Doppler findings were similar in the patient and control groups. Among tissue Doppler variables, only early diastolic mitral annular velocity (Em) was significantly decreased (10±2.9 vs. 11.4±3.2 cm/sec, p<0.05), and accordingly, mitral inflow E/Em ratio was significantly increased (7.3±2.5 vs. 6.3±2, p<0.05) in patients with DM. The two groups were similar with respect to systolic S and Sr values, except for apical-lateral S, mid-anterior S, basal-anteroseptal S, apical-anterior Sr, and mid-anteroseptal Sr (p<0.05, for all). Patients with DM duration of >3 years and receiving medical therapy showed similar changes as the overall patient group.

CONCLUSION
The frequency of left ventricular diastolic dysfunction was higher in patients with DM. Irregular distribution of systolic S and Sr indices in the left ventricular segments may indicate that DM leads to heterogeneous myocardial involvement also in the early period.

Keywords: Diabetes mellitus, type 2/complications, echocardiography; myocardial contraction; stress, mechanical; ventricular function

How to cite this article
M. Sertaç Alpaydın, Enbiya Aksakal, Mustafa Kemal Erol, Ziya Şimşek, Mahmut Açıkel, Şakir Arslan, Fuat Gündoğdu, Serdar Sevimli, Şule Karakelleoğlu. Assessment of regional left ventricular functions by strain and strain rate echocardiography in type II diabetes mellitus patients without microvascular complications. Turk Kardiyol Dern Ars. 2011; 39(5): 378-384

Corresponding Author: Enbiya Aksakal, Türkiye
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