Archives of the Turkish Society of Cardiology
Successful intravenous immunoglobulin therapy in a case of acute fulminant myocarditis [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2011; 39(1): 59-63

Successful intravenous immunoglobulin therapy in a case of acute fulminant myocarditis

Tolga Ozyigit1, Zeynep Unal2, Beste Ozben3
1American Hospital, Department of Cardiology, Istanbul, Turkey
2American Hospital, Department of Radiology, Istanbul, Turkey
3Marmara University Faculty of Medicine, Department of Cardiology, Istanbul, Turkey

Fulminant myocarditis is an inflammatory process that occurs in the myocardium and causes acute-onset heart failure. Its prognosis is poor unless patients are promptly and aggressively supported. Although an autoimmune mechanism has been postulated for myocarditis, immunomodulatory treatment strategies are still under investigation. We report on a 30-year-old woman with acute myocarditis, whose condition rapidly deteriorated despite standard medical therapy. High-dose intravenous immunoglobulin therapy (70 g/day for 2 days) was given and the patient showed dramatic improvement on the second day. Left ventricular ejection fraction increased from 32% to 40% and to 50% at 24 and 48 hours of treatment, respectively. She was discharged on the tenth day with normal ejection fraction. She was free of cardiac events during a two-year follow-up. High-dose intravenous immunoglobulin may be potentially useful in selected patients, especially if given early in acute fulminant myocarditis.

Keywords: Cardiomyopathy, dilated/complications, immunoglobulins, intravenous/therapeutic use; heart failure/drug therapy; myocarditis/drug therapy

How to cite this article
Tolga Ozyigit, Zeynep Unal, Beste Ozben. Successful intravenous immunoglobulin therapy in a case of acute fulminant myocarditis. Turk Kardiyol Dern Ars. 2011; 39(1): 59-63

Corresponding Author: Beste Ozben, Türkiye
Manuscript Language: English
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