ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Evaluation of Tp-e interval and Tp-e: QT and Tp-e: QTc ratios in patients infected with HIV and using antiretroviral therapy [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2021; 49(2): 135-142 | DOI: 10.5543/tkda.2021.76656

Evaluation of Tp-e interval and Tp-e: QT and Tp-e: QTc ratios in patients infected with HIV and using antiretroviral therapy

Şükrü Çetin1, Ayşe Şabablı Çetin2, Emine Altuntaş1, Ali Bayraktar1
1Department of Cardiology, Sancaktepe Şehit Prof Dr İlhan Varank Training and Research Hospital, İstanbul, Turkey
2Department of Clinical Microbiology and İnfectious Disease, Sancaktepe Şehit Prof Dr İlhan Varank Training and Research Hospital, İstanbul, Turkey


OBJECTIVE
Sudden cardiac death (SCD) is one of the causes of death among patients infected with human immunodeficiency virus (HIV). The T peak to T end interval (Tp-e interval) is a parameter that is used in the prediction of SCD. The aim of this study was to investigate the difference in Tp-e interval and Tp: QT and Tp: corrected QT interval (QTc) ratios between patients infected with HIV and healthy individuals as well as in other factors affecting patients infected with HIV.

METHODS
A total of 83 patients infected with HIV with negative HIV ribonucleic acid (RNA) levels who were receiving antiretroviral therapy (ART) and 83 healthy individuals were included in this study. All the participants underwent electrocardiography, their Tp-e and QT intervals were measured, and QTc intervals and Tp-e: QT and Tp-e: QTc ratios were calculated. In addition, in the patients infected with HIV, CD4 and CD8 T-cell count and HIV RNA levels were measured.

RESULTS
The Tp-e interval was found to be longer and the Tp-e: QT and Tp-e: QTc ratios were found to be higher in patients infected with HIV. Nadir CD4 was observed to be an independent predictor of Tp-e interval (p=0.014, β=‒0.28). Furthermore, correlation analysis revealed a negative correlation of the nadir CD4 level and CD4: CD8 ratio with Tp-e interval and Tp-e: QT ratio.

CONCLUSION
Low nadir CD4 and a reversed CD4: CD8 ratio in patients infected with HIV receiving ART were found to be associated with a prolonged Tp-e interval and increased Tp-e: QT and Tp-e: QTc ratios. Thus, more attention should be taken in terms of SCD in patients infected with HIV, especially in those with low nadir CD4 and reversed CD4: CD8 ratio.

Keywords: HIV, CD4, CD8, Tp-e, Tp-e: QT and Tp-e: QTc ratios

How to cite this article
Şükrü Çetin, Ayşe Şabablı Çetin, Emine Altuntaş, Ali Bayraktar. Evaluation of Tp-e interval and Tp-e: QT and Tp-e: QTc ratios in patients infected with HIV and using antiretroviral therapy. Turk Kardiyol Dern Ars. 2021; 49(2): 135-142

Corresponding Author: Şükrü Çetin, Türkiye
Manuscript Language: English


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