Predictive Value of the SCORE, SCORE2 and Pooled Cohort Risk Equation Systems in Patients with Hypertension

OBJECTIVE
The objective of this study is to assess and compare the accuracy of old and new versions of European Society of Cardiology Systematic Coronary Risk Evaluation (ESC SCORE and SCORE2) and American Heart Association/ American College of Cardiology Pooled Cohort Risk Assessment Equations (AHA/ACC PCE) systems in predicting long-term cardiovascular events in patients with hypertension (HT).


METHOD
This retrospective study consisted of 788 patients (54% female, mean age 54±9 years) diagnosed with HT between 2009 and 2018. The absolute risk for 10-years cardiovascular events were calculated with SCORE, SCORE2, SCORE-OP and PCE systems based on patients’ data obtained on the date of HT diagnosis. The study group was followed for the occurrence of major adverse cardiac and cerebrovascular events (MACCE). The differences between observed and predicted risk calculated using SCORE, SCORE2 and PCE systems and their prognostic value were assessed.


RESULTS
The mean age of the 788 patients included in the study, of whom 426 (54.1%) were female, was 53.65 ± 9.08 years. Of these patients, during a mean follow-up of 6 years, 173 (22.0%) patients experienced a MACCE. In detecting occurrence of MACCE in HT patients in the long-term, AHA/ACC PCE had a predictive power comparable to ‘ESC SCORE2-SCORE-OP’, whereas ESC SCORE was inferior to ‘ESC SCORE2-SCORE-OP’.


CONCLUSION
In this study, the PCE risk-scoring system was superior to the old and new versions of SCORE risk system in predicting the cardiovascular and cerebrovascular events that developed in patients with HT.