The Correlation between Serum Uric Acid/Albumin Ratio and Circadian Rhythm of Blood Pressure in Patients with Hypertension

OBJECTIVE
A non-dipping blood pressure (BP) pattern is commonly associated with an increased risk of negative cardiovascular events. Thus, this research sought to examine the relationship between a non-dipper circadian pattern and serum uric acid / albumin ratio (UAR) observed in individuals with hypertension.

METHODS
Our research encompasses 340 consecutive patients who underwent ambulatory blood pressure monitoring (ABPM) from June 2022 to June 2023. By virtue of the circadian BP pattern obtained from 24-h ABPM, all patients were separated into 2 different groups as dipping and non-dipping. The non-dipper group was determined based on the decline less than 10% in the blood pressure value measured at night.

RESULTS
The UAR levels in patients exhibiting a non-dipper pattern were significantly elevated compared to those in to dipper group. Higher UAR rates were determined to be separately connected with the existence of non-dipper pattern as a result of multivariate logistic regression analysis. Via the ROC (receiver operating characteristic) curve analysis, UAR values above 1.30 indicated a sensitivity of 66.5% and a specificity of 65.9% in estimating the non-dipper pattern [AUC (Area Under the Curve): 0.738, 95% Confidence Interval: 0.688-0.790; p<0.001].

CONCLUSION
UAR can be an easily obtained and calculated biomarker for identifying patients prone to hypertensive patterns that do not decrease during the night. Thus, hypertensive patients at increased risk for adverse atherosclerotic cases in the future can be identified and closely monitored, and more intensive treatment options can be applied to these patients.