Turk Kardiyol Dern Ars. 2015; 43(3): 242-249 | DOI: 10.5543/tkda.2015.72025
Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement
Mustafa Ozan Gürsoy1
, İrfan Tursun2
, Mehmet Alpua2
, Aslı Haykır Solay3
, Müge Tokat Çobanlı3
, Hale Demirtaş1
, Gülten Ercan4
, Semra Gürsoy4
, Macit Kalçık5
, Süleyman Karakoyun6
, Mehmet Özkan71
Department Of Cardiology, Iğdır State Hospital, Iğdır, Turkey2
Department Of Internal Medicine, Iğdır State Hospital, Iğdır, Turkey3
Department Of Infectious Diseases, Iğdır State Hospital, Iğdır, Turkey4
Department Of Pediatrics, Iğdır State Hospital, Iğdır, Turkey5
Department Of Cardiology, Koşuyolu Kartal Heart Training And Research Hospital, Istanbul, Turkey6
Department Of Cardiology, Doğubeyazıt State Hospital, Ağrı, Turkey7
Department Of Cardiology, Kars Kafkas University, Faculty Of Medicine, Kars, Turkey
OBJECTIVE Brucellosis is an important infectious disease, especially in developing countries, and may involve any organ, including the cardiovascular system. This study aimed to assess cardiac and endothelial functions in brucellosis patients.
METHODS Seventy-three patients with brucellosis and seventy- five healthy volunteers from Turkey were enrolled between 2011 and 2013 in this cross-sectional study. Diagnosis was established by the Rose-Bengal test, positive Brucella standart tube agglutination test, and Coombs STA and/or isolation Brucella species from blood. Cases were divided into three groups: Group I; acute brucellosis, Group II; subacute brucellosis, and Group III; chronic brucellosis. Healthy individuals comprised Group IV. All patients underwent transthoracic echocardiography and brachial artery flow-mediated dilatation (FMD) test.
RESULTS Groups I to IV comprised 35, 18, and 20 patients, and 75 controls respectively. The most frequent symptoms were arthralgia (82%), fever (92%), and fatigue (97%). Echocardiography revealed no difference among the 4 groups regarding left ventricular systolic and diastolic functions and valvular functions. Brachial artery diameter after hyperemia was significantly different among the groups (p=0.002). Post hoc test showed Group III to have significantly lower brachial artery diameter after hyperemia compared to other groups (p=0.02, p=0.004 and p=0.001, respectively). FMD was also significantly lower in Group III compared to Groups I, II and IV (p<0.001 for each).
CONCLUSION Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement.
Brucellosis, echocardiography; endothelial dysfunction; flow-mediated dilatation
How to cite this article
Mustafa Ozan Gürsoy, İrfan Tursun, Mehmet Alpua, Aslı Haykır Solay, Müge Tokat Çobanlı, Hale Demirtaş, Gülten Ercan, Semra Gürsoy, Macit Kalçık, Süleyman Karakoyun, Mehmet Özkan. Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement. Turk Kardiyol Dern Ars. 2015; 43(3): 242-249
Corresponding Author: Mustafa Ozan Gürsoy, Türkiye
Manuscript Language: English