Archives of the Turkish Society of Cardiology
Investigation of metabolic effects of CETP gene rs289714 variation in coronary artery patients: A case-control study [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2020; 48(7): 673-682 | DOI: 10.5543/tkda.2020.70124

Investigation of metabolic effects of CETP gene rs289714 variation in coronary artery patients: A case-control study

Özlem Kurnaz Gömleksiz1, Zeynep Karaali2, Zehra Buğra3, Oğuz Öztürk4, Hulya Yilmaz Aydogan4
1Department of Medical Biology, Faculty of Medicine, Altinbas University, İstanbul, Turkey
2Department of Internal Diseases, Haseki Training and Research Hospital, Health Science University, İstanbul, Turkey
3Department of Cardiology, Istanbul Faculty of Medicine,Istanbul University, Istanbul, Turkey
4Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey


OBJECTIVE
The aim of this study was to investigate the effects of the CETP gene rs289714 polymorphism on the serum lipid profile and other metabolic parameters in Turkish patients with coronary artery disease (CAD).

METHODS
The CETP rs289714 variant was examined in 104 patients with CAD and 77 controls using the polymerase chain reaction-restriction fragment length polymorphism method.

RESULTS
The CETP rs289714 genotype and allele distribution was not statistically different between the groups (p>0.05). The body mass index (BMI) values in men with CAD were higher in patients with the G allele compared with those carrying the AA genotype (p=0.05). Logistic regression analysis showed that the G allele in male CAD patients was a risk factor for a BMI of 27 kg/m2 (odds ratio: 0.269, 95% confidence interval: 0.075–0.966; p=0.044). The G allele in female patients was associated with lower HDL-C levels than the AA genotype (p=0.049).

CONCLUSION
The results suggest that the CETP rs289714 polymorphism may cause risk for the development of CAD due to its effects on high-density lipoprotein cholesterol values in male patients and BMI in female patients.

Keywords: CETP, coronary artery disease; rs289714; body mass index; high-density lipoprotein cholesterol.

How to cite this article
Özlem Kurnaz Gömleksiz, Zeynep Karaali, Zehra Buğra, Oğuz Öztürk, Hulya Yilmaz Aydogan. Investigation of metabolic effects of CETP gene rs289714 variation in coronary artery patients: A case-control study. Turk Kardiyol Dern Ars. 2020; 48(7): 673-682

Corresponding Author: Özlem Kurnaz Gömleksiz, Türkiye
© Copyright 2020 Archives of the Turkish Society of Cardiology
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