Turk Kardiyol Dern Ars. 2020; 48(1): 20-25 | DOI: 10.5543/tkda.2019.69256
The prognostic value of vitamin D level for in-hospital mortality in patients with acute pulmonary embolism
Veysel Ozan Tanık1
, Tufan Çınar2
, Barış Şimşek31
Department of Cardiology, Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey2
Department of Cardiology, Health Sciences University, Sultan Abdülhamid Han Training and Research Hospital, İstanbul, Turkey3
Department of Cardiology, Health Sciences University, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center Training and Research Hospital, İstanbul, Turkey
OBJECTIVE The aim of this study was to investigate the prognostic value of the serum vitamin D (Vit-D) level on admission in patients with acute pulmonary embolism (APE) to determine in-hospital mortality.
METHODS Ninety-nine patients who were diagnosed with APE between January 2015 and January 2018 and had a record of an admission serum Vit-D level were enrolled in the study. The serum Vit-D level was measured using an immune-based assay in all cases. The primary outcome of the study was in-hospital all-cause mortality.
RESULTS The study population was divided into 2 groups according to the median value of serum Vit-D level: Vit-D level ≤7.36 ng/mL in 49 patients and Vit-D level >7.36 ng/mL in 50 patients. The patients with a serum Vit-D level ≤7.36 ng/mL had a higher of incidence of in-hospital death compared with those whose serum Vit-D level was >7.36 ng/mL (6 [12.2%] vs. 1 [2%]; p=0.048). In Cox regression analysis, the serum Vit-D level (Hazard ratio: 0.82, 95% confidence interval: 0.68-0.98; p=0.043) was found to be independently associated with in-hospital mortality. The optimal value of serum Vit-D level for the prediction of in-hospital mortality was ≤6.47 ng/mL, with a sensitivity of 71.4% and a specificity 86.9% (area under the curve: 0.81, 95% CI: 0.720.88; p=0.004).
CONCLUSION The findings demonstrated that the serum Vit-D level on admission may be an independent predictor for in-hospital mortality in patients with APE.
Acute pulmonary embolism, in-hospital mortality, prognostic value; vitamin D.
How to cite this article
Veysel Ozan Tanık, Tufan Çınar, Barış Şimşek. The prognostic value of vitamin D level for in-hospital mortality in patients with acute pulmonary embolism. Turk Kardiyol Dern Ars. 2020; 48(1): 20-25
Corresponding Author: Tufan Çınar, Türkiye