ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Long-Term Natural Course of Patients with Pulmonary Artery Pressures in the Range of 21–24 mmHg: Insights from a Single-Center Study [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2023; 51(7): 478-485 | DOI: 10.5543/tkda.2023.65724

Long-Term Natural Course of Patients with Pulmonary Artery Pressures in the Range of 21–24 mmHg: Insights from a Single-Center Study

Burcu Yağmur, Meral Kayıkçıoğlu, Evrim Şimşek, Sanem Nalbantgil, Hakan Kültürsay
Department of Cardiology, Ege University Faculty of Medicine, İzmir, Türkiye


OBJECTIVE
Slightly elevated mean pulmonary artery pressure (mPAP) was previously termed as ‘’borderline pulmonary hypertension (PH)’’. We examined the long-term prognosis of patients with mPAP values between 21 and 24 mmHg, who were referred with the suspicion of pulmonary hypertension.


METHODS
Our retrospective study included patients with moderate-to-high echocardiographic risk who underwent right heart catheterization (RHC) between 2008 and 2021 and were followed for at least 1 year. Patients with mPAP <21 mmHg and mPAP 21–24 mmHg were compared. Demographic and clinical characteristics and prognoses of the groups were compared. All-cause mortality over a mean follow-up of 5 years (min 1–max 13 years) was evaluated.


RESULTS
A total of 140 patients (mean age 53.1 ± 14.8 years, female 74.5%) with mPAP values <25 mmHg measured of the 395 diagnostic RHCs. Mean follow-up was 4.92 ± 3.13 years. NT-pro-BNP and 6-min walking distance were better in patients with mPAP <21 mmHg. Echocardiographic findings suggestive of PH were more common in mPAP 21–24 mmHg group (P < 0.05). Both the pulmonary artery wedge pressure and cardiac index values were significantly deteriorated in individuals with mPAP 21–24 mmHg (P = 0.001). All-cause mortality tended to be higher in the borderline PH group but did not reach to statistical significance.


CONCLUSION
Our single-center observational study revealed that the individuals with an mPAP of 21–24 mmHg tended to have a worser prognosis than those with mPAP of <21 mmHg for up to 13-year follow-up.

Keywords: Invasive hemodynamics, pulmonary artery pressure, pulmonary hypertension, right heart catheterization, survival

How to cite this article
Burcu Yağmur, Meral Kayıkçıoğlu, Evrim Şimşek, Sanem Nalbantgil, Hakan Kültürsay. Long-Term Natural Course of Patients with Pulmonary Artery Pressures in the Range of 21–24 mmHg: Insights from a Single-Center Study. Turk Kardiyol Dern Ars. 2023; 51(7): 478-485

Corresponding Author: Burcu Yağmur
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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