Turk Kardiyol Dern Ars. Ahead of Print: TKDA-62874 | DOI: 10.5543/tkda.2020.62874
Association of APOA5 -1131T>C polymorphism with obesity in coronary artery disease
, Aybike Sena Ozuynuk1
, Aycan Fahri Erkan2
, Berkay Ekici2
, Maide Kaşit1
, Nihan Erginel-Unaltuna11
Department Of Genetics, Aziz Sancar Institute For Experimental Medicine, Istanbul University2
Department Of Cardiology, Medical Faculty, Ufuk University
OBJECTIVE Genetic risk factors that cause coronary artery disease (CAD) show variations in different populations. In this study, to determine the genetic contributors of CAD, a single nucleotide polymorphism (SNP) in APOA5 gene was targeted and its effects were examined on the development of CAD and known risk factors of the disease.
METHODS 448 patients with angina or acute myocardial infarction who underwent coronary angiography were grouped as individuals with normal coronary arteries (≤30% stenosis) and critical disease (≥50% stenosis). The angiographic severity and the extent of atherosclerotic CAD were assessed using Gensini and SYNTAX scores. Individuals were genotyped for APOA5 −1131T>C polymorphism using hydrolysis probes and the results were statistically evaluated.
RESULTS In this study, APOA5 −1131T>C polymorphism was associated with serum lipid levels in non-CAD (p<0.05). In addition, a borderline association was found between APOA5 −1131T>C and type 2 diabetes mellitus (p=0.055). This polymorphism was found associated with obesity and it was observed that APOA5 -1131C allele carriers had decreased risk for obesity (p<0.05). Furthermore, logistic regression analysis adjusted for age and gender was showed that APOA5 -1131C allele carriage had a protective effect against obesity in the study group (OR: 0.48, 95% CI: 0.29-0.78, p=0.003).
CONCLUSION In this study, APOA5 gene polymorphism, which is shown as one of the genetic factors that may lead to atherosclerotic CAD, was found associated with obesity in study group. In conclusion, APOA5 −1131T>C polymorphism has been associated with important risk factors of the CAD such as obesity and serum lipid levels.
APOA5 gene, polymorphism, CAD, obesity
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Corresponding Author: neslihan coban, Türkiye