ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Impact of Enalapril on Reflex Vagal Activity After Acute Myocardial Infarction: Probable Prognostic Improvement [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1995; 23(5): 343-349

Impact of Enalapril on Reflex Vagal Activity After Acute Myocardial Infarction: Probable Prognostic Improvement

Kadir GÜRKAN1, Dursun ÜNAL1, Ayşe EMRE1, Hasan SUNAY1, Recep ÖZTÜRK1, Ümit İÇER1, Tanju ULUFER1, Birsen ERSEK1, Aydın ÇAĞIL1, Tezer ULUSOY1

Baroleflex sensitivity (BRS) is predictor of lethal arrhythmias and cardiac sudden death after acute myocardial infarction (AMI). Despite the fact that angiotensin convertign enzyme inhibitors (ACEI) were shown to increase the vagal activity, their effects on BRS after AMI are yet to determined. Hence, we aimed to assess the effects of ACEI on BRS values after AMI. 15 cases with anterior AMI, who were given early thrombolytic therapy, were enrolled into the study. After phenylephrine test was performed on the third of fourt in-hospital days to obtain BRS values, 10 randomized cases were given enalpril 5 mg bid orally, and the remaining 5 were included in the control group. The phenylephrine test was repeated three days later. While the mean BRS value rose from 5.6±3.6 msec/mmHg to 8±4.5 msec/mmHg (p<0.001) after enalapril administration, it decreased from 9±7.5 msec/mmHg to 7.4±5.2 msec/mmHg in the control group. BRS increase of about 2.4±1.6 msec/mmHg induced by enalapril was significantly different from the BRS decrease of about 1.6±3.6 msec/mmHg that was determined as control value, although the difference between the corresponding first and second mean BRS values among the two groups were not statistically significant (p>0.2, p>0.3). Thus, enalapril significantly improves reflex vagal activity in uncomplicated AMI cases during in-hospital days.

Keywords: Enalapril, myocardial infarction, reflex vagal activity

How to cite this article
Kadir GÜRKAN, Dursun ÜNAL, Ayşe EMRE, Hasan SUNAY, Recep ÖZTÜRK, Ümit İÇER, Tanju ULUFER, Birsen ERSEK, Aydın ÇAĞIL, Tezer ULUSOY. Impact of Enalapril on Reflex Vagal Activity After Acute Myocardial Infarction: Probable Prognostic Improvement. Turk Kardiyol Dern Ars. 1995; 23(5): 343-349
Manuscript Language: Turkish


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

Quick Search



Copyright © 2024 Archives of the Turkish Society of Cardiology



Kare Publishing is a subsidiary of Kare Media.