Archives of the Turkish Society of Cardiology
Increased epicardial fat thickness is associated with low grade systemic inflammation in metabolic syndrome [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2012; 40(8): 690-695 | DOI: 10.5543/tkda.2012.60207

Increased epicardial fat thickness is associated with low grade systemic inflammation in metabolic syndrome

Derya Tok, İskender Kadife, Osman Turak, Fırat Özcan, Nurcan Başar, Kumral Çağlı, Dursun Aras, Serkan Topaloğlu, Sinan Aydoğdu
Department of Cardiology, Yüksek Ihtisas Education and Research Hospital, Ankara, Turkey


OBJECTIVES
Epicardial fat tissue is a type of visceral adipose tissue that functions as a metabolically active endocrine organ. Most components of metabolic syndrome (MetS), especially visceral obesity, are associated with a low-grade systemic inflammatory state. In this study, we aimed to assess the relationship between echocardiographic epicardial fat thickness (EFT), MetS, the components of MetS, and high sensitivity C-reactive protein (hs-CRP) levels in patients with MetS.

STUDY DESIGN
Forty-six patients (25 males, mean age 47.3±6.5 years) with the diagnosis of MetS (according to the Adult Treatment Panel III update criteria) but without clinical coronary artery disease, and 44 age and gender matched healthy volunteers (18 males, mean age 46.0±6.1 years) were included in the study. EFT, which was measured by transthoracic echocardiography, as well as clinical and biochemical parameters were compared between the two groups.

RESULTS
Waist circumference, total and LDL-cholesterol, fasting glucose, triglycerides, systolic and diastolic blood pressure levels, hs-CRP, and uric acid levels were significantly higher in patients with MetS. EFT was also significantly increased in patients with MetS (8.7±0.2 mm vs. 4.8±0.1 mm, p<0.001). Multiple regression analysis determined that MetS itself (β=0.929, p<0.001) and hs-CRP (r=-0.181, p=0.007) are independent predictors of increased EFT.

CONCLUSION
This study demonstrates that EFT is higher in patients with MetS, and that MetS and hsCRP are independent predictors of this increased EFT. Increased EFT, which is associated with low-grade systemic inflammation, may play a role in the pathogenesis of atherosclerosis in MetS patients.

Keywords: Adipose tissue/pathology, atherosclerosis, echocardiography, metabolic syndrome X

How to cite this article
Derya Tok, İskender Kadife, Osman Turak, Fırat Özcan, Nurcan Başar, Kumral Çağlı, Dursun Aras, Serkan Topaloğlu, Sinan Aydoğdu. Increased epicardial fat thickness is associated with low grade systemic inflammation in metabolic syndrome. Turk Kardiyol Dern Ars. 2012; 40(8): 690-695

Corresponding Author: Derya Tok, Türkiye
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