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Archives of the Turkish Society of Cardiology
The Prognostic Value of the Triglyceride-Glucose Index in Forecasting Ten-Year Major Adverse Cardiovascular Events in Non-Diabetic Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2024; 52(4): 253-259 | DOI: 10.5543/tkda.2023.58554

The Prognostic Value of the Triglyceride-Glucose Index in Forecasting Ten-Year Major Adverse Cardiovascular Events in Non-Diabetic Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Uğur Köktürk1, Orhan Onalan2, Mustafa Umut Somuncu3, Begüm Uygur4, İlke Erbay2, Fahri Çakan5, Ahmet Avcı1
1Department of Cardiology, Faculty of Medicine, Zonguldak Bülent Ecevit University, Zonguldak, Türkiye
2Department of Cardiology, Karabuk University Training and Research Hospital, Karabuk, Türkiye
3Department of Cardiology, Faculty of Medicine, Aydın Adnan Menderes University, Aydın, Türkiye
4Department of Cardiology, University of Health Sciences, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Türkiye
5Department of Cardiology, Cerkezkoy State Hospital, Tekirdag, Türkiye


OBJECTIVE
This study aimed to explore the association between the triglyceride-glucose (TyG) index and major adverse cardiovascular events (MACE) over a ten-year period in non-diabetic patients with acute myocardial infarction (MI) undergoing primary percutaneous coronary intervention (PCI).


METHODS
We included 375 consecutive non-diabetic patients presenting with acute MI who underwent primary PCI. The TyG index was calculated and patients were divided based on a cut-off value of ≥ 8.84 into high and low TyG index groups. The incidence of MACE, including all-cause mortality, target vessel revascularization, reinfarction, and rehospitalization for heart failure, was assessed over 10 years.


RESULTS
Over the next 10 years, patients who underwent PCI for acute MI experienced a significantly higher incidence of MACE in the group with a high TyG index (≥ 8.84) (P = 0.004). Multivariable analysis revealed that the TyG index independently predicted MACE in these patients [odds ratio = 1.64; 95% confidence interval (CI): 1.22-2.21; P = 0.002]. Analysis of the receiver operating characteristic curve indicated that the TyG index effectively predicted MACE in patients with acute MI following PCI, with an area under the curve of 0.562 (95% CI: 0.503-0.621; P = 0.038).


CONCLUSION
This study established a correlation between high TyG index levels and an elevated risk of MACE in non-diabetic patients with acute MI. The findings suggest that the TyG index could be a reliable indicator of clinical outcomes for non-diabetic acute MI patients undergoing PCI.

Keywords: Acute myocardial infarction, major adverse cardiovascular events, percutaneous coronary intervention, triglyceride-glucose index

How to cite this article
Uğur Köktürk, Orhan Onalan, Mustafa Umut Somuncu, Begüm Uygur, İlke Erbay, Fahri Çakan, Ahmet Avcı. The Prognostic Value of the Triglyceride-Glucose Index in Forecasting Ten-Year Major Adverse Cardiovascular Events in Non-Diabetic Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention. Turk Kardiyol Dern Ars. 2024; 52(4): 253-259

Corresponding Author: Uğur Köktürk
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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