ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
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Serum YKL–40/chitinase 3–like protein 1 level is an independent predictor of atherosclerosis development in patients with obstructive sleep apnea syndrome [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2015; 43(4): 333-339 | DOI: 10.5543/tkda.2015.56805

Serum YKL–40/chitinase 3–like protein 1 level is an independent predictor of atherosclerosis development in patients with obstructive sleep apnea syndrome

Eftal Murat Bakirci1, Edhem Unver2, Husnu Degirmenci1, Tulay Kivanc3, Murat Gunay4, Hikmet Hamur1, Mutlu Buyuklu1, Gokhan Ceyhun1, Ergun Topal1, Taha Abdulkadir Coban4
1Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey
2Department of Pulmonary Diseases, Faculty of Medicine, Erzincan University, Erzincan, Turkey
3Department of Pulmonary Diseases, Faculty of Medicine, Baskent University, Konya, Turkey
4Department of Biochemistry, Faculty of Medicine, Erzincan University, Erzincan, Turkey


OBJECTIVE
The inflammatory process plays an important role in the development of cardiovascular complications in patients with obstructive sleep apnea syndrome (OSAS). YKL-40/chitinase 3–like protein 1 is a novel biomarker of systemic inflammation. This study aimed to investigate whether carotid intima-media thickness (CIMT), a useful marker for early atherosclerosis, is associated with serum YKL–40/chitinase 3–like protein 1 levels in patients with normotensive and nondiabetic OSAS.

METHODS
The study included 40 OSAS patients and 40 agesex- and body mass index-matched healthy controls. Serum YKL–40 levels were detected by enzyme-linked immunosorbent assay. CIMT was measured by B-mode ultrasound.

RESULTS
The patients with OSAS had significantly increased CIMT and higher YKL–40 and high sensitivity C-reactive protein (hsCRP) levels than those of the controls. CIMT was strongly correlated with serum YKL–40 levels (r=0.694, p<0.001), hsCRP (r=0.622, p<0.001), age (r=0.525, p=0.001), and weakly correlated with apnea-hypopnea index (AHI) (r=0.365, p=0.021) and the percentage of recording time spent (PRTS) of oxygen saturation <90% (r=0.488, p=0.001). Moreover, it was detected that serum YKL-40 levels were strongly correlated with AHI (r=0.617, p<0.001), and weakly correlated with SaO2 <90% of PRTS (r=0.394, p=0.012) and hsCRP (r=0.486, p=0.001). In multiple regression analyses, age and serum levels of YKL–40 and hsCRP were found to be independent predictors of CIMT.

CONCLUSION
In patients with OSAS, CIMT was increased. This increase was associated with serum YKL–40 level. Increased serum level of YKL–40 may be an early predictor of atherosclerosis development in patients with OSAS.

Keywords: Carotid intima-media thickness, coronary artery disease, inflammation; sleep apnea, obstructive; YKL-40

How to cite this article
Eftal Murat Bakirci, Edhem Unver, Husnu Degirmenci, Tulay Kivanc, Murat Gunay, Hikmet Hamur, Mutlu Buyuklu, Gokhan Ceyhun, Ergun Topal, Taha Abdulkadir Coban. Serum YKL–40/chitinase 3–like protein 1 level is an independent predictor of atherosclerosis development in patients with obstructive sleep apnea syndrome. Turk Kardiyol Dern Ars. 2015; 43(4): 333-339

Corresponding Author: Eftal Murat Bakirci, Türkiye
Manuscript Language: English


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Journal Citation Indicator: 0.18
CiteScore: 1.1
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SCImago Journal Rank: 0.348

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