Assessment of the Efficacy of HALP Score of Recurrence of Atrial Fibrillation Post Cryo-balloon Ablation

OBJECTIVE
Hemoglobin, Albumin, Lymphocyte, Platelet Score (HALP) has gained interest as a potential predictive biomarker for predicting diverse clinical outcomes across multiple diseases. This study aimed to evaluate the efficacy of the HALP score in estimating the recurrence of atrial fibrillation (AF) after cryo-balloon ablation (CBA).

METHODS
The study included 399 patients who underwent CBA due to AF and were divided into three equal groups based on their HALP score, and post-procedure AF recurrence was evaluated retrospectively across the groups.

RESULTS
After adjusting for confounding independent parameters, patients included in Tertile 1 were found to have 2.1 times higher rates of the recurrence of AF compared to Tertile 3, which was presumed as the reference group. ROC curve analysis indicated that the HALP score predicted AF recurrence with an AUC of 0.69, 65% sensitivity, and 65% specificity. (HR: 0.69, 95% CI: 0.63-0.74, p <0.001)

CONCLUSION
This study established that the HALP score may function as an independent predictor of AF recurrence after CBA.