ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Pulmonary and ventricular functions in children with repaired tetralogy of Fallot [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2015; 43(6): 542-550 | DOI: 10.5543/tkda.2015.52498

Pulmonary and ventricular functions in children with repaired tetralogy of Fallot

Savaş Demirpençe1, Barış Güven2, Murat Muhtar Yılmazer3, Taliha Öner3, Önder Doksöz3, Rahmi Özdemir3, Hikmet Tekin Nacaroğlu4, Timur Meşe3, Vedide Tavlı1, Demet Can4
1Sifa University Faculty of Medicine, Department of Pediatric Cardiology, Bornova, Izmir, Turkey
2Izmir University Faculty of Medicine, Medical Park Hospital, Department of Pediatric Cardiology, Karşıyaka, Izmir, Turkey
3Behçet Uz Children Hospital, Departments of Pediatric Cardiology, Alsancak, Izmir, Turkey
4Behçet Uz Children Hospital, Departments of Pediatric Allergy and Immunology, Alsancak, Izmir, Turkey


OBJECTIVE
This study aimed to evaluate biventricular function, brain natriuretic peptide levels, respiratory function test and 6 minute walking test (6MWT) in children with repaired tetralogy of Fallot (TOF), and analyse the correlation between these variables and clinical status.

METHODS
Twenty-five children (14 boys, 11 girls; aged 6 to 17 years) with repaired TOF (Group 1) and 25 age-sex matched healthy controls (Group 2) were enrolled in the study. Tissue Doppler echocardiography, respiratory function test, 6MWT distance and brain natriuretic peptide levels were measured.

RESULTS
Mean ages of the children at TOF corrective surgery and at study time were 5.1±3.5 years and 11.6±2.7 years respectively. The duration between palliative operation and corrective surgery was 4.3±2.0 years, and the follow-up period after corrective surgery was 6.3±3.0 years. The right ventricular and left ventricular myocardial performance indices (MPIs), and isovolumic relaxation and contraction times were significantly higher in Group 1 than in Group 2 (p<0.01). Spirometry displayed significantly reduced forced vital capacity (FVC), forced expiratory volume in one second (FEV1), forced expiratory flow 25–75% (FEF25–75) and inspirational capacity in Group 1 compared to Group 2 (p<0.01). In Group 1, 6MWT distances were significantly lower than in Group 2 (p=0.001). Right ventricular MPI is correlated with FEV1, FVC and 6MWT distance in the current study.

CONCLUSION
The children with repaired TOF had impaired ventricular and pulmonary functions. Hence, right ventricular MPI along with FEV1, FVC and 6MWT distance may be useful in the follow-up of children with repaired TOF.

Keywords: Natriuretic peptide, brain, tetralogy of Fallot, tissue Doppler echocardiography, six minute walking test; respiratory function test

How to cite this article
Savaş Demirpençe, Barış Güven, Murat Muhtar Yılmazer, Taliha Öner, Önder Doksöz, Rahmi Özdemir, Hikmet Tekin Nacaroğlu, Timur Meşe, Vedide Tavlı, Demet Can. Pulmonary and ventricular functions in children with repaired tetralogy of Fallot. Turk Kardiyol Dern Ars. 2015; 43(6): 542-550

Corresponding Author: Savaş Demirpençe, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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