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Archives of the Turkish Society of Cardiology
The Use of Cangrelor as Bridge Antiplatelet Therapy in a Patient with Recent Percutaneous Coronary Intervention for Acute Coronary Syndrome, Who Developed Esophageal Perforation After Transesophageal Echocardiography [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2024; 52(5): 352-356 | DOI: 10.5543/tkda.2023.50000

The Use of Cangrelor as Bridge Antiplatelet Therapy in a Patient with Recent Percutaneous Coronary Intervention for Acute Coronary Syndrome, Who Developed Esophageal Perforation After Transesophageal Echocardiography

Ulviyya Guliyeva1, Kurtuluş Karaüzüm1, İsa Çam2, Revan İsrafilov1, Ahmet Faruk Koç1, Didar Mirzamidinov1, Hasan Yılmaz3, İrem Karaüzüm1, Tayfun Şahin1, Ertan Ural1
1Department of Cardiology, Kocaeli University Medical Faculty, Kocaeli, Türkiye
2Department of Radiology, Kocaeli University Medical Faculty, Kocaeli, Türkiye
3Department of Gastroenterology, Kocaeli University Medical Faculty, Kocaeli, Türkiye

Dual antiplatelet therapy (DAPT) is a vital part of the pharmacological management in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). While early discontinuation of DAPT increases ischemic risk, some patients on DAPT may require urgent surgery, necessitating its interruption. Cangrelor, an intravenous P2Y12 antagonist, provides strong platelet inhibition within minutes and platelet activity normalizes within one hour after the cessation of the drug. Bridging antiplatelet therapy with cangrelor has been increasingly studied as an alternative option to ensure the continuation of platelet inhibition in CAD patients who require discontinuation of DAPT. The present patient, with a recent history of PCI for acute coronary syndrome, experienced a significant esophageal perforation following transesophageal echocardiography (TEE). This severe complication was effectively managed endoscopically, and as part of the recent PCI treatment, prolonged cangrelor infusion was successfully utilized with no thrombotic or bleeding events throughout the management of the complication.

Keywords: Antiplatelet, cangrelor, esophageal perforation, transesophageal echocardiography

How to cite this article
Ulviyya Guliyeva, Kurtuluş Karaüzüm, İsa Çam, Revan İsrafilov, Ahmet Faruk Koç, Didar Mirzamidinov, Hasan Yılmaz, İrem Karaüzüm, Tayfun Şahin, Ertan Ural. The Use of Cangrelor as Bridge Antiplatelet Therapy in a Patient with Recent Percutaneous Coronary Intervention for Acute Coronary Syndrome, Who Developed Esophageal Perforation After Transesophageal Echocardiography. Turk Kardiyol Dern Ars. 2024; 52(5): 352-356

Corresponding Author: Kurtuluş Karaüzüm, Türkiye
Manuscript Language: English


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