ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Assessment of NOAC Dosing Patterns in Turkish Patients with Non-Valvular Atrial Fibrillation: A Multicenter, Cross-Sectional Study with Insights from the ASPECT-NOAC Study [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. Ahead of Print: TKDA-47718 | DOI: 10.5543/tkda.2024.47718

Assessment of NOAC Dosing Patterns in Turkish Patients with Non-Valvular Atrial Fibrillation: A Multicenter, Cross-Sectional Study with Insights from the ASPECT-NOAC Study

Özer Badak1, Demet Özkaramanlı Gür2, Çağlar Kaya3, Tugay Önal4, Onur Saydam4, İbrahim Faruk Aktürk5, Servet Altay3, Ahmet Altuğ Çinçin6, Refik Emre Altekin7, Göksel Çağırcı8, Kadriye Kılıçkesmez9, Veli Polat5, Dursun Aras10
1Department of Cardiology, Dokuz Eylül University, Faculty of Medicine, İzmir, Türkiye
2Department of Cardiology, Namık Kemal University Health Application and Research Hospital, Tekirdağ, Türkiye
3Department of Cardiology, Trakya University Health Research and Application Center, Edirne, Türkiye
4Medical Department of Internal Medicine, Pfizer, Istanbul, Türkiye
5Department of Cardiology, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Türkiye
6Department of Cardiology, Marmara University Pendik Training and Research Hospital, İstanbul, Türkiye
7Department of Cardiology, Akdeniz University Hospital, Antalya, Türkiye
8Department of Cardiology, Antalya Training and Research Hospital, Antalya, Türkiye
9Department of Cardiology, Sisli Hamidiye Etfal Training and Research Hospital, İstanbul, Türkiye
10Department of Cardiology, Istanbul Medipol University Bahcelievler Hospital, İstanbul, Türkiye


OBJECTIVE
We aimed to assess the real‐world label adherence of non‐vitamin K antagonist oral anticoagulant (NOAC) dosing patterns, including apixaban, edoxaban, and rivaroxaban in Turkish patients with atrial fibrillation.

METHODS
This was an observational, prospective, cross-sectional, multicenter study. Patients with AF who were prescribed NOACs within the last 4 months were recruited from 34 cardiology clinics in Turkey. Baseline data were initially collected, and patient awareness was evaluated at 3–4 weeks.

RESULTS
A total of 903 patients were enrolled in the study. The mean age was 72.84 ± 10.17 years. We found that 140 (15.5%), 721 (79.8%), and 42 patients (4.7%) were prescribed off-label low, on-label, and off-label high dosing, respectively. The age of the patients in the on-label group was significantly lower than that of those in the off-label low and off-label high groups (both p<0.001). Female patients were more frequently observed in the off-label high group (p=0.019). The body mass index values of the patients in the off-label high-dose group were significantly lower than those in the other groups (p<0.001). The perception of income levels also revealed significant differences between the groups (p=0.010). Furthermore, the HAS-BLED scores were significantly lower in the on-label group than in the other groups (p<0.001). Similarly, the CHA2DS2-VASc scores were significantly lower in the on-label group than in the off-label group (p<0.001).

Keywords: Anticoagulants, atrial fibrillation, dosing pattern, NOACs, patient medication knowledge

How to cite this article


Corresponding Author: Onur Saydam, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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