Low amplitude signals (LP) at the end of the QRS in patients with acute myocardial infaretion CAMI) are related to fragmentation of the electrical impulse in ventricular myocardium and detected on signalaveraged electrocardiography. In this study, w e investigated the use of glucose-insulin-potassium (GlK) solution and its effects on the SAECG in AMI.
METHODS Seventy-two consec utive patients diagnosed with first Q-wave AMI were prospectively studied. Thrombolytic therapy was given to all patients unless contraindicated. The patients were randomly given glucose-insulin-potassium (GlK, n=34) solutions which consisted of 300 g of glucose, 50 units of insulin and 80 mEq of KCl in 1000 cc water placebo (saline, n.38). Ambulatory electrocardiographic examinations were performed in all patients between 24-48th hours. S ub-maxi ınal exercise testing (if not contraindicated), s ignalaveraged e lectrocardiogram (SAECG) and echocardiographic records were obtained before discharge (6-9, mean 7 days). In postdischarge early period (in 30-40 days after index infarction) SAECG and echocardiography recordings were repeated.
RESULTS There were no differences found between both groups in view of ages, number of risk factors, Iocalization of infarction. In pre-di sc harge evaluations total filtered QRS durat ion (FQRS ı: ı 03±7 msec vs I 08± ı ı msec p<0.05), Iow-amplitude terminal signal d uration (HFLA ı: 25±8 msec vs 32±1 I msec, p
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