Turk Kardiyol Dern Ars. Ahead of Print: TKDA-45605 | DOI: 10.5543/tkda.2020.45605
New Indicator of Cellular Ischemia in Coronary Slow Flow Phenomenon; Cell-Free DNA
, Ali Dogan1
, nuri kurtoglu1
, veysel sabri hancer2
, MEHMET GÜRBÜZEL31
Department of Cardiology, Yeni Yuzyil Universty, Istanbul, Turkey2
Department of Medical Genetics, Istinye University, Istanbul, Turkey3
Department of Medical Biology, Erzincan Universty, Erzincan, Turkey
OBJECTIVE Coronary slow flow phenomenon (CSFP) is defined as the delayed arrival of coronary blood flow to distal vascular bed at least in one major epicardial coronary artery. Cell-free DNA (cfDNA) is a type of DNA that circulates freely in blood after being released from nucleated cells. The present study aims to demonstrate whether the level increases of the cfDNA in CSFP, which are indicator of ischemia at the cellular level.
METHODS The study included 46 patients in total, 23 patients with CSFP, 23 with normal coronary angiograms (NCA). cfDNA levels, clinical, biochemical and angiographic features of the groups were compared.
RESULTS The mean age was 53.8±10.3 years for the CSFP patients and 56.6±9.4 years for the NCA patients. There was no statistically significant difference between the groups in terms of basal clinical characteristics and laboratory data of patients. Plasma cfDNA levels were 5.04±2.37 ng/µl in CSFP patients and 2.28±1.09 ng/µl in the NCA group (p<0.001).
CONCLUSION Different invasive and noninvasive studies conducted on patients with the CSFP have also shown myocardial ischemia. In our study, we showed that the levels of cfDNA, a marker of cellular ischemia and damage, have increased significantly as a result of ischemia at cellular level caused by microvascular disruption in patients with CSFP.
Cell-Free Nucleic Acids, Myocardial ischemia, Coronary slow flow phenom-enon
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Corresponding Author: mustafa yolcu, Türkiye