Essential hypertension coexists with immune system disturbances of cellular as well as humoral links. We propose to consider these disturbances for administering hypertensive therapy as the potential benefit of blood pressure reduction may be compromised if immune system parameters are deteriorated on the background of treatment. Thus, thiazide diuretics result in unfavourable changes of immune system; in contrast to them, calcium channel blockers and alpha- blockers are "immunoneutral" and only ACE inhibitors possess a favourable effect of varying degree on the immune state of hypertensive patients.
Keywords: Antihypertensive therapy, essential hypertension, immune disturbances, cellular immunity, humoral immunity, immunocorrectionCopyright © 2025 Archives of the Turkish Society of Cardiology