ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Genetic Polymorphism on Chromosome 4q25 (rs17570669) May Predict Recurrence After Successful Electrical Cardioversion in Patients with Persistent Atrial Fibrillation [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2023; 51(8): 550-556 | DOI: 10.5543/tkda.2023.37679

Genetic Polymorphism on Chromosome 4q25 (rs17570669) May Predict Recurrence After Successful Electrical Cardioversion in Patients with Persistent Atrial Fibrillation

Taner Ulus1, İlkin Aliyev1, Serap Arslan2, Oğuz Çilingir3, Ertuğrul Çolak4
1Department of Cardiology, Eskişehir Osmangazi University, Eskişehir, Türkiye
2Department of Medical Genetics, Karabük University, Karabük, Türkiye
3Department of Medical Genetics, Eskişehir Osmangazi University, Eskişehir, Türkiye
4Department of Biostatistics, Eskişehir Osmangazi University, Eskişehir, Türkiye


OBJECTIVE
Direct current electrical cardioversion (DCCV) is an effective rhythm-control option for patients with atrial fibrillation (AF). Despite initial success, a high recurrence rate remains a significant challenge. There is limited data on the genetic predictors of AF recurrence following successful DCCV. In this study, we aimed to evaluate whether 11 single nucleotide polymorphisms (SNPs) previously associated with AF are also linked to recurrence after DCCV in the Turkish population.


METHODS
Seventy-five patients with persistent AF, who achieved stable sinus rhythm following DCCV, were included in the study. The patients were prospectively monitored for the onset of AF recurrence. Clinical characteristics and SNPs were analyzed and compared between patients who experienced recurrence and those who did not.


RESULTS
The average age of the patients was 61.9 ± 11.5, and 33 (44%) were female. Over an average follow-up period of 17.0 (11.0-25.0) months, AF recurrence was observed in 38 patients (50.7%). A SNP in the PITX2 gene (rs17570669) (OR: 9.00, 95% Confidence Interval (CI): 1.28-63.02) and another in the ZFHX3 gene (rs2106261) (OR: 8.96, 95% CI: 1.03-77.66) were notably associated with AF recurrence in the additive model (P = 0.027 and 0.047, respectively). Multivariate Cox regression analysis revealed that the rs17570669 SNP was the sole independent predictor of AF recurrence (Hazard Ratio (HR): 3.59, 95% CI: 1.05-12.21, P = 0.040).


CONCLUSION
The SNP in the paired-like homeodomain 2 (PITX2) gene (rs17570669) emerges as an independent predictor for AF recurrence after successful electrical cardioversion.

Keywords: Atrial fibrillation, electrical cardioversion, single nucleotide polymorphism

How to cite this article
Taner Ulus, İlkin Aliyev, Serap Arslan, Oğuz Çilingir, Ertuğrul Çolak. Genetic Polymorphism on Chromosome 4q25 (rs17570669) May Predict Recurrence After Successful Electrical Cardioversion in Patients with Persistent Atrial Fibrillation. Turk Kardiyol Dern Ars. 2023; 51(8): 550-556

Corresponding Author: Taner Ulus, Türkiye
Manuscript Language: English


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