Archives of the Turkish Society of Cardiology
Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2008; 36(8): 536-540

Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease

Murat Rabus1, Recep Demirbağ2, Yusuf Sezen2, Oğuz Konukoğlu1, Ali Yildiz2, Özcan Erel3, Rahmi Zeybek1, Cevat Yakut1
1Department Of Cardiovascular Surgery, Kartal Kosuyolu Heart And Research Hospital, Istanbul, Turkey.
2Department Of Cardiology, Medical Faculty Of Harran University, Sanliurfa, Turkey
3Department Of Biochemistry, Medical Faculty Of Harran University, Sanliurfa, Turkey


OBJECTIVES
We investigated whether patients with rheumatic and degenerative heart valve disease (HVD) differed with regard to plasma and tissue oxidative stress index (OSI).

STUDY DESIGN
The study included 56 patients who underwent valve replacement due to rheumatic (n=32; 15 males; mean age 47±10 years) and degenerative (n=24; 13 males; mean age 55±12 years) HVD. Plasma and tissue total oxidative status (TOS) and total antioxidative capacity (TAC) levels were measured and OSI was calculated.

RESULTS
Patients with degenerative HVD had significantly higher age, increased interventricular septum thickness, and higher frequency of aortic stenosis, whereas the incidence of mitral stenosis was higher in patients with rheumatic HVD (p<0.05). Plasma oxidative characteristics did not differ between the two HVD groups (p>0.05). Tissue TAC was significantly lower in patients with rheumatic HVD (p=0.027), whereas tissue TOS and OSI were similar between the two HVD groups (p>0.05). In bivariate analysis, plasma OSI did not show any correlation with clinical, laboratory, and echocardiographic variables (p>0.05).

CONCLUSION
Our data show that plasma and tissue OSI levels are similar in patients with rheumatic and degenerative HVD.

Keywords: Antioxidants, biological markers, heart valve diseases, oxidative stress; rheumatic heart disease

How to cite this article
Murat Rabus, Recep Demirbağ, Yusuf Sezen, Oğuz Konukoğlu, Ali Yildiz, Özcan Erel, Rahmi Zeybek, Cevat Yakut. Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. Turk Kardiyol Dern Ars. 2008; 36(8): 536-540

Corresponding Author: Murat Rabus, Türkiye
Manuscript Language: English
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