Archives of the Turkish Society of Cardiology
Effects of Antihypertensive Therapy with Amlodipine on Left Ventricular Mass and Diastolic Function [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1995; 23(5): 336-342

Effects of Antihypertensive Therapy with Amlodipine on Left Ventricular Mass and Diastolic Function

Ali S. FAK1, Metin OKUCU1, Hakan TEZCAN1, Gökhan BODUR1, Ahmet OKTAY1

The effect of antihypertensive therapy with amlodipine on left ventricular mass and diastolic function was examined. After a wash-out period of 2 weeks and a single-blind placebo period of 4 weeks, patients found to have mild to moderate systemic heypertension, left ventricular hypertrophy (LVH) and diastolic dysfunction (DD) with echo-Doppler were included in the study. LVH was described as left ventricular mass index (LVMI) > 134 g/m2 in men and > 110 g/m2 in women and DD as mitral inflow E/A < 1. Amlodipine was given 5 mg daily and if neccessary was increased to 10 mg in the 4th week and continued for 6 months. 30 patients in the sixth month with controlled hypertension were reevaluated. Blood pressure decreased from 164±13/104±6 to 134±10/84±5 in the 3rd month (p<0.01) and to 131±10/85±5 mmHg in the 6th month. LVMI decreased from 157.7±30 to 135.7±27.2 in the 3rd month (p<0.01) and to 131.8±24.9 g/m2 in the 6th month (p<0.01). The regression of LVH was seen to be due mainly on the regression of septal thickness (12.8±0.2 baseline, 11.7±1.8 in 3 months p<0.05, and 11.2±1.8 p<0.01, in 6 months). Although a small improvement in E/A ratio was observed in 6 months, the change was not significant. In conclusion; 1) amlodipine was found to be effective in reducing LVH in patients with mild to moderate hypertension, 2) the regression in LVH was persistent in 6 months, 3) the regression in LVH was mainly due to regression in septal thickness and 4) despite blood pressure control and regression in left ventricular mass, a significant improvement in diastolic function was not achieved.

Keywords: Systemic hypertension, left ventricular hypertrophy, amlodipine

How to cite this article
Ali S. FAK, Metin OKUCU, Hakan TEZCAN, Gökhan BODUR, Ahmet OKTAY. Effects of Antihypertensive Therapy with Amlodipine on Left Ventricular Mass and Diastolic Function. Turk Kardiyol Dern Ars. 1995; 23(5): 336-342
Manuscript Language: Turkish
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