ISSN 1016-5169 | E-ISSN 1308-4488
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Rationale, design and methodology of the RAMSES Study: ReAl-life Multicenter Survey Evaluating Stroke Prevention Strategies [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2016; 44(3): 215-220 | DOI: 10.5543/tkda.2015.29266

Rationale, design and methodology of the RAMSES Study: ReAl-life Multicenter Survey Evaluating Stroke Prevention Strategies

Özcan Başaran1, Volkan Dogan1, Kadriye Memic Sancar1, İbrahim Altun1, Kadir Ugur Mert1, Gurbet Özge Mert1, Nesrin Filiz Başaran2, Edip Güvenç Çekiç2, Cevat Kırma3, Murat Biteker1
1Department Of Cardiology, Mugla Sitki Kocman University Faculty Of Medicine, Mugla, Turkey
2Department Of Pharmacology, Mugla Sitki Kocman University Faculty Of Medicine, Mugla, Turkey
3Department of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, Turkey


OBJECTIVE
Atrial fibrillation is the most common arrhythmia and is associated with a five- fold increased risk of thromboembolic events. Vitamin K antagonists (VKAs) have been the mainstay of oral anticoagulant prophylaxis and the data on stroke prevention strategies are limited to VKA era. The purpose of this study is to evaluate the use of VKA, non-Vitamin K antagonist oral anticoagulants (NOAC), and antiplatelet agents in patients with non-valvular atrial fibrillation (NVAF).

METHODS
The ReAl-life Multicenter Survey Evaluating Stroke prevention strategies in Turkey (RAMSES) is an observational, multicenter, prospective study of patients with NVAF. The study targeted enrollment of 7835 patients from 68 sites in Turkey. All the data will be collected at one point in time and current clinical practice will be evaluated. (ClinicalTrials.gov number NCT02344901).

RESULTS
Baseline characteristics of patients, antithrombotic therapies, transition to NOACs and rate/rhythm control strategies will be evaluated.

CONCLUSION
The RAMSES registry will be the largest study in Turkish NVAF patients. The study will provide insights into real-world problems and anticoagulant treatment in patients with NVAF.

Keywords: Atrial fibrillation, oral anticoagulant; risk scores; stroke; Turkey

Corresponding Author: Özcan Başaran, Türkiye
Manuscript Language: English
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