Archives of the Turkish Society of Cardiology
Relationship between plasma asymmetric dimethylarginine leveland autonomic dysfunction in diabetic patients [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2012; 40(2): 148-154 | DOI: 10.5543/tkda.2012.01826

Relationship between plasma asymmetric dimethylarginine leveland autonomic dysfunction in diabetic patients

Ahmet Akyel1, Atiye Çengel2, Yusuf Tavil2, Asife Şahinarslan2, Salih Topal2, Çağrı Yayla2, Şehri Elbeğ3, Bülent Boyacı2, Metin Arslan4
1Etlik Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, Turkey
2Gazi University Medical Faculty, Department of Cardiology, Ankara, Turkey
3Gazi University Medical Faculty, Department of Biochemistry, Ankara, Turkey
4Gazi University Medical Faculty, Department of Endocrinology, Ankara, Turkey


OBJECTIVES
We aimed to investigate the relationship between plasma asymmetric dimethylarginine (ADMA) levels and heart rate variability (HRV) in diabetic patients.

STUDY DESIGN
The study included 100 patients (44 men, 56 women) with type 2 diabetes mellitus. The patients were divided into two groups based on the use of oral antidiabetics (n=67; mean age 54.6±7.8 years) or insulin (n=33; mean age 51.6±8.8 years). Plasma ADMA levels were measured and HRV parameters were calculated from 24-hour Holter EKG recordings. The findings were compared with those of a control group consisting of 42 nondiabetic individuals (mean age 52.8±6.2 years).

RESULTS
Compared to the control group, plasma ADMA levels were significantly higher (p=0.007) and all HRV parameters were significantly reduced in both diabetic groups. However, ADMA levels and HRV parameters were similar in the two diabetic groups (p>0.05). Correlation analysis showed no significant relationship between plasma ADMA levels and HRV parameters.

CONCLUSION
Our findings show that plasma ADMA levels are increased and HRV is reduced in diabetic patients, indicating that these patients have both endothelial dysfunction and autonomic dysfunction, but plasma ADMA levels cannot be used to evaluate autonomic dysfunction.

Keywords: Arginine, autonomic nervous system; biological markers; diabetes mellitus, type 2; endothelium, vascular; heart rate

How to cite this article
Ahmet Akyel, Atiye Çengel, Yusuf Tavil, Asife Şahinarslan, Salih Topal, Çağrı Yayla, Şehri Elbeğ, Bülent Boyacı, Metin Arslan. Relationship between plasma asymmetric dimethylarginine leveland autonomic dysfunction in diabetic patients. Turk Kardiyol Dern Ars. 2012; 40(2): 148-154

Corresponding Author: Ahmet Akyel, Türkiye
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