Role of Dobutamine 99mTc-Tetrofosmin Myocardial Perfusion SPECT in the Detection of Coronary Artery Disease

This study investigates the significance of dobutamine 99ınTc-tetrofosmin myocardial perfusion SPECT in the detection of coronary artery disease (CAD). Among those referred to the Nuclear medicine department of the Istanbul University , fstanbul Medical Faculty, 26 patients with CAD were incİuded in the study. Dobutamine infusion was init iated ata dose of 5 j.lg/kg/min and gradually increased to 1 O, 20, 30 and to a maximum dose of 40 j.lg/kg/min every 3 minutes. Following cessation of the planned dobuta mine perfusion, 8-1 O m Ci 99ınTc-tetrofosmin w as injected and stres SPECT images were obtained. After 3 hours, resting SPECT images were taken following 14-22 mCi 99mTc-tetrofosmin injection. With doses of and above 10 pg/kg/min dobutamine perfusion, increases in heart rate and systolic blood pressure were found to be statistically significant (pKeywords: Coronary heart disease, Dobutamine - SPECT