Archives of the Turkish Society of Cardiology
Differences in autoimmunity factors based on the activity of thromboangiitis obliterans [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2021; 49(6): 439-447 | DOI: 10.5543/tkda.2021.19014

Differences in autoimmunity factors based on the activity of thromboangiitis obliterans

Abbas Shapouri-Moghadam1, Seyed Jalil Tavakkol Afshari1, Mohammad- Hadi Saeed Modaghegh2, Mahmoud Mahmoudi1, Hamid Reza Rahimi3, Seyed Morteza Ehteshamfar1
1Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2Vascular and Endovascular Surgery Research Center, Alavi Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


OBJECTIVE
The treatment of Buerger’s disease (BD) presents a medical problem as its etiology is still unclear. In this study, our objective was to evaluate the serum levels of autoimmune markers in patients with different clinical features of BD.

METHODS
In this study, 80 BD patients were categorized in three groups using a cross-sectional design: migratory thrombophlebitis, cold sensitivity, and skin discoloration (mild symptoms); chronic ulcers, claudication, and burning pain of the feet at night (moderate symptoms); pain at rest and spontaneous gangrene (severe symptoms). Enzyme-linked immunosorbent assay was performed to measure antibodies against immunoglobulin M rheumatoid factor (IgM RF), anti-nuclear antibodies (ANA), antibodies against cyclic citrullinated peptide (anti-CCP), antiphospholipid antibodies (APA), anti-cardiolipin antibodies (ACLA), anti-double stranded DNA (anti-dsDNA), and extractable nuclear antigen (ENA) profile.

RESULTS
Patients with severe symptoms showed the lowest age (p=0.031), ESR (p<0.001), and highest prevalence of ischemia (p<0.001). In all the patients, the serum levels of ANA and IgM RF were higher than 1 U and 15 IU/mL, respectively. However, the progression of the disease from mild to moderate did not affect these markers significantly (p>0.05). Other markers were negative in patients with BD.

CONCLUSION
The findings of this study indicate that BD may closely be correlated to transient autoimmune phenomena, despite the fact that further research is required to investigate how transient unspecific autoimmune reactions contribute to the BD pathogenesis.

Keywords: Thromboangiitis obliterans, disease progressions, antibodies, autoimmune disease

How to cite this article
Abbas Shapouri-Moghadam, Seyed Jalil Tavakkol Afshari, Mohammad- Hadi Saeed Modaghegh, Mahmoud Mahmoudi, Hamid Reza Rahimi, Seyed Morteza Ehteshamfar. Differences in autoimmunity factors based on the activity of thromboangiitis obliterans. Turk Kardiyol Dern Ars. 2021; 49(6): 439-447

Corresponding Author: Abbas Shapouri-Moghadam, Iran
© Copyright 2021 Archives of the Turkish Society of Cardiology
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