Turk Kardiyol Dern Ars. 2021; 49(7): 536-544 | DOI: 10.5543/tkda.2021.11292
The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins
, Serkan Ünlü1
, Gökhan Gökalp1
, Niyazi Samet Yılmaz2
, Özlem Gülbahar2
, Adnan Abacı11
Department of Cardiology, Gazi University School of Medicine, Ankara, Turkey2
Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey
OBJECTIVE Myocardial injury related to percutaneous coronary interventions (PCI) might adversely affect the prognosis of patients with coronary artery disease. Our study aimed to investigate the effects of long-term statin usage on myocardial injury related to elective PCI.
METHODS In our study, total 102 patients were included and evaluated in 3 groups based on the statin usage before PCI, potent statin group (n=26), weak statin group (n=23), and statin free group (n=53). The occurrence of the procedural complications was identified (n=31). The myocardial injury was determined by serial high-sensitivity troponin T (hsTnT) testing at 0th, 2nd, 4th, and 12th hour of the procedure.
RESULTS The increase in hsTnT values in the 2nd and 4th hour was significantly lower in the potent statin group than in the other 2 groups (p=0.008 and p=0.009, respectively). In patients with procedural complications, the increase in hsTnT levels at the 2nd, 4th, and 12th hour were also lower in the potent statin group (p=0.032, p=0.019, and p=0.006, respectively). Also, in patients with procedural complications, hsTnT levels exceeding the myocardial infarction limit at the 4th and 12th hour were lower in the potent statin group (p=0.039 and p=0.006, respectively).
CONCLUSION These results show that elective PCI related myocardial injury was less frequent in patients who were using high-dose statins. This result was more pronounced in patients who developed complications during the procedure.
Percutaneous coronary intervention, High-sensitivity troponins, Myocardial injury, Statins
How to cite this article
Ajar Koçak, Serkan Ünlü, Gökhan Gökalp, Niyazi Samet Yılmaz, Özlem Gülbahar, Adnan Abacı. The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins. Turk Kardiyol Dern Ars. 2021; 49(7): 536-544
Corresponding Author: Adnan Abacı, Türkiye