ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
The Effect of Number of Pregnancies on Aortic Stiffness Index, Aortic Velocity Propagation, and Epicardial Fat Thickness [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2024; 52(7): 519-526 | DOI: 10.5543/tkda.2024.07486

The Effect of Number of Pregnancies on Aortic Stiffness Index, Aortic Velocity Propagation, and Epicardial Fat Thickness

Faysal Şaylık1, Tufan Çınar2, Tayyar Akbulut1, Mert İlker Hayıroğlu3, Murat Selçuk2, Zeynep Sevde Serdaroğlu Uzuner4, Mehmet Saygı5, Remziye Doğan5, İbrahim Halil Tanboğa6
1Department of Cardiology, Van Training and Research Hospital, Van, Türkiye
2Department of Cardiology, Sultan Abdulhamid Han Training and Research Hospital, İstanbul, Türkiye
3Department of Cardiology, Dr. Siyami Ersek Training and Research Hospital, İstanbul, Türkiye
4Department of Obstetrics and Gynecology, Van Training and Research Hospital, Van, Türkiye
5Department of Cardiology, Hisar Intercontinental Hospital, İstanbul, Türkiye
6Departments of Cardiology and Biostatistics, Nisantası University, İstanbul, Türkiye


OBJECTIVE
Pregnancy causes physiological, hormonal, and hemodynamic changes that affect the aortic wall dimensions and elastic properties. Multiple pregnancies increase the risk of aortic enlargement and reduce aortic elasticity. The aortic stiffness index (ASI) and aortic velocity propagation (AVP) are markers of elasticity. Additionally, epicardial fat thickness (EFT) is associated with cardiovascular risk factors. The impact of multiparity on ASI, AVP, and EFT has not been previously reported in the literature. Therefore, we aimed to investigate the association of these parameters with the number of live pregnancies in this study.


METHODS
A total of 410 patients were enrolled in this prospective study. Patients were divided into three groups based on the number of live births: Group 1 (n = 0, 128 patients), Group 2 (4 ≥ n > 0, 157 patients), and Group 3 (n ≥ 5, 125 patients). A linear regression analysis was conducted to investigate trend associations of ASI, AVP, and EFT between the study groups. Multiple linear regression analysis was used to evaluate the independent predictors of continuous parameters.


RESULTS
There were increasing trends in multiparity with variables such as aortic systolic (ASD) and diastolic diameters, pulmonary artery diameters, ASI, and EFT, and a decreasing trend in AVP. The number of pregnancies was strongly and positively correlated with ASI, moderately and positively correlated with EFT and ASD, and moderately and negatively correlated with AVP.


CONCLUSION
Multiparity was independently associated with ASI, EFT, ASD, and AVP, reflecting decreased elasticity and elevated cardiovascular risk in multiparous women.

Keywords: Aortic stiffness index, aortic velocity propagation, epicardial fat thickness, multiparity

Corresponding Author: Faysal Şaylık
Manuscript Language: English
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Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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