ISSN 1016-5169 | E-ISSN 1308-4488
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Human neutrophil peptides 1-3 level in patients with acute myocardial infarction and its relation with coronary artery disease severity [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2021; 49(2): 120-126 | DOI: 10.5543/tkda.2021.99537

Human neutrophil peptides 1-3 level in patients with acute myocardial infarction and its relation with coronary artery disease severity

Fahrettin Katkat1, Sinan Varol1, Nilgün Işıksaçan3, Fatma Nihan Turhan Çağlar2, Fatih Akın4, Dilay Karabulut2, Ertuğrul Okuyan1
1Department of Cardiology, Bağcılar Training and Research Hospital, İstanbul, Turkey
2Department of Cardiology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey
3Department of Biochemistry, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey
4Department of Cardiology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Turkey


OBJECTIVE
Inflammation plays a crucial role in the pathogenesis and clinical outcome of atherosclerosis. Among the various inflammatory factors, antimicrobial peptides, such as alpha-defensins, seem to contribute to the development and progression of atherosclerosis. The aim of this study was to evaluate the plasma levels of human neutrophil peptide-1, -2, and -3 (HNP1–3) in patients with acute myocardial infarction (AMI) and to assess its relationship with the severity of coronary artery disease.

METHODS
Plasma HNP1–3 levels in patients with AMI and controls with angiographically normal coronary arteries were measured by solid-phase enzyme-linked immunosorbent assay. In the patient group, coronary artery disease severity was assessed using the SYNergy between percutaneous intervention with TAXus and cardiac surgery score (SS).

RESULTS
HNP1–3 levels were significantly higher in the group with AMI than in the controls (6.5±5.8 ng/mL vs. 2.8±2.5 ng/mL, p<0.001). The receiver operator characteristic (ROC) analysis yielded a cut-off value of 3.13 ng/mL for differentiating patients with AMI from the controls (area under the curve: 0.739, 95% confidence interval: 0.629–0.831, p<0.001). HNP1–3 levels in the high SS tertile (≥33) were slightly but statistically nonsignificantly higher than that in the low (≤22) and intermediate SS tertiles (high SS: 7.0±6.1 ng/mL, intermediate SS: 5.9±6.2 ng/mL, low SS: 5.3±3.8 ng/mL; p=0.639).

CONCLUSION
Patients with AMI had higher plasma HNP1–3 levels than the controls, but this did not show a significant correlation with angiographic disease severity. The nonsignificant trend toward higher SS in patients with higher HNP1–3 levels warrants future studies on larger populations.

Keywords: Acute myocardial infarction, human neutrophil peptide-1, -2 and 3, atherosclerosis

Corresponding Author: Fahrettin Katkat, Türkiye
Manuscript Language: English
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