ISSN 1016-5169 | E-ISSN 1308-4488
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The Influence of Low and Iso-osmolar Contrast Media on Diagnostic Performance of Contrast Fractional Flow Reserve Measurement [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2022; 50(4): 264-269 | DOI: 10.5543/tkda.2022.21273

The Influence of Low and Iso-osmolar Contrast Media on Diagnostic Performance of Contrast Fractional Flow Reserve Measurement

Reza Rahmani1, Mohammad Ramezani1, Akbar Shafiee2
1Department of Cardiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
2Department of Cardiovascular Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran


OBJECTIVE
For fractional flow reserve measurement, contrast media can be used as an alternative for adenosine. However, contrast media with different physical characteristics (e.g., osmolality and viscosity) may have different effects on hyperemia. This study aimed to determine if the diagnostic accuracy of contrast fractional flow reserve was influenced by 2 commonly used contrast media (Visipaque and Ultravist).

METHODS
In this diagnostic study, candidates for coronary angiography with intermediate coronary lesion were enrolled and randomized to receive either an iso-osmolar contrast media (Visipaque) or a low osmolar contrast media (Ultravist) for fractional flow reserve measurement. The gold standard was fractional flow reserve measured by adenosine fractional flow reserve. Then cFFR and adenosine fractional flow reserve were compared between the groups, and the diagnostic values of both contrasts were calculated. Finally, the cut-point for diagnosing adenosine fractional flow reserve ≤ 0.8 was calculated for cFFR in both groups.

RESULTS
In this study, 46 patients were studied (24 patients received Ultravist and 22 patients received Visipaque). There was no significant difference between the groups in adenosine fractional flow reserve. Also, the mean cFFR was not different from the mean adenosine fractional flow reserve in both groups. There was a strong correlation between cFFR and adenosine fractional flow reserve for each of the contrasts (r=0.937 for Ultravist and r=0.927 for Visipaque). Both contrasts had high specificity to diagnose fractional flow reserve ≤ 0.8 (specificity=1), and the sensitivities of cFFR for Ultravist and Visipaque were 83.3% and 94.7%. The cut-point to predict adenosine fractional flow reserve ≤ 0.80 was 0.845 for Ultravist and 0.835 for Visipaque.

CONCLUSIONS
Both iso-osmolar or low osmolar contrast media have an acceptable diagnostic accuracy in measuring cFFR.

Keywords: Coronary artery disease, coronary angiography, fractional flow reserve, adenosine, contrast media

How to cite this article
Reza Rahmani, Mohammad Ramezani, Akbar Shafiee. The Influence of Low and Iso-osmolar Contrast Media on Diagnostic Performance of Contrast Fractional Flow Reserve Measurement. Turk Kardiyol Dern Ars. 2022; 50(4): 264-269

Corresponding Author: Akbar Shafiee
Manuscript Language: English


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