Cyclophilin A And D Levels In The Acute Coronary Syndrome, And Their Relationship With Cardiovascular Risk Factors

OBJECTIVE
We aimed to evaluate cyclophilin levels in patients with acute coronary syndrome (ACS) and their relationship with the clinical characteristics of the patients.
Material and
METHODS
One hundred fifty patients with ACS (n=75 STEMI, n=75 NSTEMI) were enrolled. For comparison, 25 healthy volunteers were also included in the study. Cardiovascular risk factors from the medical history of patients were evaluated. Troponin T, CK-MB, and lipid panel were routinely analyzed at admission. Cyclophilin A, cyclophilin D, and CRP levels were measured in acute myocardial infarction (AMI) groups and healthy group. The effects of cardiovascular risk factors including diabetes mellitus, hypertension, dyslipidemia, age, gender, and smoking on these parameters were examined.

RESULTS
Cyclophilin A levels were significantly lower in the STEMI group, cyclophilin D and CRP levels were significantly higher in all AMI groups (P<0.05). There was a negative correlation between cyclophilin A and troponin T and CK-MB (respectively r=-0.287, P<0.001, r=-0.231, P=0.005), while Cyclophilin D and cardiac markers were no correlation. There was a positive correlation between cyclophilin D and CRP (r=0.219, P=0.004). Cyclophilin A was associated with hypertension, while Cyclophilin D was found to be associated female gender, and dyslipidemia (P<0.05).

CONCLUSION
The present study suggests that decreased cyclophilin A for more severe disease in STEMI and increased cyclophilin D in both STEMI and NSTEMI may be valuable markers. Therefore, more detailed studies should be conducted to monitor their changes and interactions in ACS patients.