ISSN 1016-5169 | E-ISSN 1308-4488
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The Role of Biomarkers in Predicting Cognitive Impairment in Elderly Patients with Heart Failure [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2024; 52(4): 244-252 | DOI: 10.5543/tkda.2024.97143

The Role of Biomarkers in Predicting Cognitive Impairment in Elderly Patients with Heart Failure

Ayça Arslan1, Ahmet Çelik2, Oben Döven2
1Department of Cardiology, Kafkas University Medical Faculty, Kars, Türkiye
2Department of Cardiology, Mersin University Medical Faculty, Mersin, Türkiye


OBJECTIVE
This study explores the impact of sST2, Growth Differentiation Factor 15 (GDF-15), and clinical factors on cognitive dysfunction in elderly patients with heart failure with reduced ejection fraction (HFrEF).


METHODS
A cohort of 101 chronic stable HFrEF patients aged over 65 years old participated in the study. Cognitive functions were assessed using the Montreal Cognitive Assessment (MoCA) test and the Mini Mental State Examination (MMSE). Levels of sST2, GDF-15, and N-terminal pro b-type natriuretic peptide (NT-proBNP) were also measured.


RESULTS
Notably higher levels of NT-proBNP and GDF-15 were observed in the group with cognitive dysfunction, whereas sST2 levels were similar between the groups. The cognitive dysfunction group consisted of older patients. A higher proportion of patients with normal cognitive function had received influenza vaccinations. Furthermore, GDF-15 levels inversely correlated with MMSE score. Right ventricular diameter was negatively correlated, while hemoglobin levels were positively correlated with both MoCA and MMSE scores. Logistic regression analysis identified increased GDF-15 levels, older age, and advanced New York Heart Association (NYHA) classes as predictors of higher cognitive dysfunction risk, whereas influenza vaccination was linked to a reduced risk of cognitive dysfunction.


CONCLUSION
Cognitive dysfunction in elderly patients with heart failure may be influenced by factors such as age, right ventricular enlargement, anemia, NYHA functional class, and levels of GDF-15 and NT-proBNP.

Keywords: Cognitive dysfunction, GDF-15, heart failure, NT-proBNP, sST2

How to cite this article
Ayça Arslan, Ahmet Çelik, Oben Döven. The Role of Biomarkers in Predicting Cognitive Impairment in Elderly Patients with Heart Failure. Turk Kardiyol Dern Ars. 2024; 52(4): 244-252

Corresponding Author: Ayça Arslan, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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