ISSN 1016-5169 | E-ISSN 1308-4488
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Reviews Low Levels of High-Density Lipoproteins in the Turkish Population: A Risk Factor for Coronary Heart Disease [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1999; 27(1): 37-43

Reviews Low Levels of High-Density Lipoproteins in the Turkish Population: A Risk Factor for Coronary Heart Disease

Robert W. MAHLEY1, Thomas P. BERSOT1

Low levels of high-density lipoprote in cholesterol (HDL-C) are ın ore coınınon in Turkey than in any other population that has been studied. These low HDL-C levels occur irrespective of regional differences in dietary fat consumption, which s ignificantly alter low-density lipoprote in cholesterol levels. About 50% of Turk ish men and about 25% of Turkish women have undesirably low HDL-C levels of <35 mg/di. Increased hepatic lipase activ ity (25-30% higher levels coın pare d with American controls and presumably of genetic origin) appears to account for the generalized low HDL-C. In association with high Jevels of hepatic lipase, secondary e nvironınen ta l and metabolic factors, such as sın ok ing, physical inactivity, obesity, and diets that raise Lriglyceride levels, could further tower HDL-C. Although ınany Turks have low total cholesterol levels, the very low HDL-C causes the total cholesterol/HDL-C ratio to be dangerously high. Even at a "normal" total cholesterol level of 200 mg/di, an HDL-C !eve! of 35 mg/dl results in a ratio of 5.7. In every country studied, this ratio is clearly associated with a high risk of coronary heart disease. Thus, it is necessary to define what is a normal cholesterol !eve! in the context of low HDLC. Recent data from elinical trials now indicate thal treating patients who have low HDL-C and decreasing their total cholesterol/HDL-C ratio are beneficial in both priınary and secondary prevention of heart disease.

Keywords: Hepatic lipase, high density lipoproteins, statins, total cholesteroi/HDL-C rat io

How to cite this article
Robert W. MAHLEY, Thomas P. BERSOT. Reviews Low Levels of High-Density Lipoproteins in the Turkish Population: A Risk Factor for Coronary Heart Disease. Turk Kardiyol Dern Ars. 1999; 27(1): 37-43
Manuscript Language: Turkish


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